{"id":"W2902745272","doi":"10.1016/j.jacl.2018.11.007","title":"Individualized low-density lipoprotein cholesterol reduction with alirocumab titration strategy in heterozygous familial hypercholesterolemia: Results from an open-label extension of the ODYSSEY LONG TERM trial","year":2018,"lang":"en","type":"article","venue":"Journal of clinical lipidology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Regeneron Pharmaceuticals; Sanofi; Mylan; Pfizer; Amgen","keywords":"Medicine; Familial hypercholesterolemia; Alirocumab; Open label; Open label study; Ldl cholesterol; Internal medicine; Low-density lipoprotein; Lipoprotein; Endocrinology; Cholesterol; Clinical trial; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006147411,0.0002431164,0.001553565,0.0001462082,0.0001058518,0.00005102043,0.0004879852,0.0006120434,0.00001179581],"category_scores_gemma":[0.001216911,0.0001479974,0.000249755,0.0002479581,0.0004719666,0.0004282317,0.0001529628,0.001321669,0.000004185208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008564501,"about_ca_system_score_gemma":0.0007775887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001399494,"about_ca_topic_score_gemma":0.001797313,"domain_scores_codex":[0.9933215,0.002199413,0.002827333,0.0005281255,0.0008121431,0.0003115366],"domain_scores_gemma":[0.9959406,0.0002158041,0.001893681,0.001011523,0.0006742993,0.0002641406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6029494,0.007200644,0.01459135,0.0001202226,0.0007933265,0.0001294001,0.0009609117,0.00004851383,0.03241663,0.00001598876,0.0004838685,0.3402897],"study_design_scores_gemma":[0.203414,0.02653605,0.7630431,0.0008293497,0.0004081388,0.0007464971,0.0001411378,0.00005297259,0.004333043,0.000181327,0.0001326155,0.0001817574],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942498,0.0000608849,0.0002151693,0.00109134,0.002759613,0.001497474,0.00001813976,0.00001087164,0.00009670536],"genre_scores_gemma":[0.9886389,0.00009236886,0.001000902,0.0008143159,0.009350399,0.00001050347,0.00002774666,0.00003044367,0.00003442962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7484518,"threshold_uncertainty_score":0.6035157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1164184743422068,"score_gpt":0.4173407657328601,"score_spread":0.3009222913906532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}