{"id":"W2902753880","doi":"10.1016/j.expneurol.2018.11.010","title":"CNB-001, a pleiotropic drug is efficacious in embolized agyrencephalic New Zealand white rabbits and ischemic gyrencephalic cynomolgus monkeys","year":2018,"lang":"en","type":"article","venue":"Experimental Neurology","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"National Institutes of Health; Queen's University","keywords":"Medicine; Ischemia; Neurotrophic factors; Stroke (engine); Population; Brain ischemia; Pharmacology; Oxidative stress; Anesthesia; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005211433,0.000622334,0.000750858,0.0007629927,0.0003922739,0.0004585264,0.0003937813,0.0006307067,0.001296202],"category_scores_gemma":[0.0002987336,0.0002540181,0.0002768459,0.0003006416,0.00106332,0.0006138959,0.0001719456,0.0008374426,0.0003474303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000527782,"about_ca_system_score_gemma":0.0006783036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001944401,"about_ca_topic_score_gemma":0.003027241,"domain_scores_codex":[0.9996668,0.00006680072,0.00003927008,0.00006430004,0.00005353147,0.0001092805],"domain_scores_gemma":[0.9997823,0.0000349299,0.00007195071,0.00002458516,0.0000167549,0.00006948495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006120007,0.0005634647,0.0002607698,0.0001208228,0.0000212537,0.0003050013,0.00007647272,0.0001062395,0.988861,0.0004401134,0.0001628182,0.00296203],"study_design_scores_gemma":[0.0006829748,0.007025823,0.004810576,0.00002039327,0.00008418362,0.0005579969,0.00007822732,0.0008611939,0.9833714,0.0001772007,0.002312571,0.00001756264],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994752,0.001703989,0.0007829852,0.0002112685,0.00006510106,0.00007424075,0.0002544533,0.00006813728,0.002087754],"genre_scores_gemma":[0.9928163,0.001901577,0.001524934,0.0000879364,0.0000476005,0.0001469219,0.0004047805,0.00002736634,0.003042497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001944401,"threshold_uncertainty_score":0.004336178,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01851444212656543,"score_gpt":0.2677338822127311,"score_spread":0.2492194400861657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}