{"id":"W2902801700","doi":"10.2337/db18-0567","title":"Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control","year":2018,"lang":"en","type":"review","venue":"Diabetes","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; University of Toronto; Hospital for Sick Children","funders":"Alcon Research Institute; National Center for Advancing Translational Sciences; National Center for Research Resources; National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; National Human Genome Research Institute; Ophthalmic Research Institute of Australia; Biomedical Research Council; National Medical Research Council; Taichung Veterans General Hospital; Wake Forest School of Medicine; National Institutes of Health; Hjartavernd; Wellcome; Innovative Medicines Initiative; Case Western Reserve University; Novo Nordisk Fonden; Novo Nordisk; Medical Research Council; Wake Forest University; National Research Foundation of Korea; Folkhälsanin Tutkimussäätiö; National Institute for Health and Care Research; National Eye Institute; University of Dundee; Samfundet Folkhälsan; Academy of Finland; National Science Council; U.S. Department of Health and Human Services; National Institute of Diabetes and Digestive and Kidney Diseases; Helsingin ja Uudenmaan Sairaanhoitopiiri; Tenovus; Diabetes UK; National Institute on Aging; Wellcome Trust; Research to Prevent Blindness; Wilhelm och Else Stockmanns Stiftelse; National Heart, Lung, and Blood Institute; National Cancer Institute; Health Sciences Center, University of New Mexico; Harvard Catalyst; Johns Hopkins University; Massachusetts Lions Eye Research Fund; Háskóli Íslands; National Institute on Minority Health and Health Disparities; European Commission; Genentech; AstraZeneca; Jackson State University; National Health and Medical Research Council; Eli Lilly and Company; American Diabetes Association; Broad Institute; Sanofi; University of California, Irvine","keywords":"Glycemic; Genome-wide association study; Disease; Diabetes mellitus; Biology; Genetic association; Single-nucleotide polymorphism; Gene; Genetics; Medicine; Oncology; Internal medicine; Bioinformatics; Endocrinology; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008450245,0.0007421944,0.0009588407,0.000954192,0.000619482,0.00100038,0.0007855173,0.0006758989,0.001130958],"category_scores_gemma":[0.007612365,0.0004130369,0.00299098,0.001704575,0.0002595272,0.0004347215,0.001031182,0.0008744543,0.0001099665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003529361,"about_ca_system_score_gemma":0.0006870921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01348832,"about_ca_topic_score_gemma":0.01656111,"domain_scores_codex":[0.995544,0.003205092,0.0002487027,0.0006644359,0.0001999333,0.0001377894],"domain_scores_gemma":[0.9968039,0.001744628,0.0005193102,0.0006305974,0.0001329261,0.0001686729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003741874,0.000216796,0.920497,0.0002159347,0.04099092,0.0005733095,0.000385868,0.008732194,0.00613441,0.001882108,0.0008127436,0.01581685],"study_design_scores_gemma":[0.001033921,0.00103054,0.8449318,0.000112739,0.03745326,0.0007886794,0.0003198128,0.1018981,0.002379568,0.005408122,0.004571466,0.00007200102],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9784052,0.002160217,0.01732557,0.0003558645,0.00005129945,0.00004459775,0.0007434597,0.0001130721,0.0008007223],"genre_scores_gemma":[0.9931464,0.0002591294,0.005711279,0.00006106214,0.00001610877,0.00004751472,0.0004301008,0.00002016771,0.0003082352],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.01348832,"threshold_uncertainty_score":0.04468966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0403770801205469,"score_gpt":0.3157520012593611,"score_spread":0.2753749211388142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}