{"id":"W2902802838","doi":"10.1182/blood-2018-99-116827","title":"The Double-Hit Gene Expression Signature Defines a Clinically and Biologically Distinct Subgroup within GCB-DLBCL","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Simon Fraser University; Princess Margaret Cancer Centre; University of Toronto; University of British Columbia; Spinal Cord Injury BC","funders":"","keywords":"BCL6; Lymphoma; Diffuse large B-cell lymphoma; Population; Oncology; Biology; Gene signature; Gene; Internal medicine; Cancer research; Gene expression; Medicine; Genetics; B cell; Germinal center; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002831004,0.0002499593,0.0004187945,0.0007516988,0.0002156885,0.0005034279,0.0001406797,0.0002501717,0.0007200766],"category_scores_gemma":[0.0005103606,0.0001035258,0.0003347697,0.0004871515,0.0003593524,0.0001558328,0.0003165564,0.000308458,0.0001841154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002985895,"about_ca_system_score_gemma":0.0002469556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001446679,"about_ca_topic_score_gemma":0.001605626,"domain_scores_codex":[0.9997978,0.00003427207,0.00001278265,0.00006203297,0.0000429926,0.00005016599],"domain_scores_gemma":[0.9997264,0.0001016592,0.00005890621,0.00003247134,0.0000268584,0.00005377423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008815596,0.00006893947,0.8445683,0.0000402499,0.0001099203,0.0003634735,0.0001067384,0.001890895,0.1410806,0.0002181304,0.0001751983,0.01049598],"study_design_scores_gemma":[0.00002419285,0.0003100662,0.9688981,0.000006565911,0.00007222134,0.001206634,0.0002147328,0.01896368,0.008904247,0.0008278505,0.0005604255,0.00001131199],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984896,0.00009042615,0.001047135,0.00001772403,0.000001418571,0.00000709473,0.0001504051,0.00001619845,0.0001800317],"genre_scores_gemma":[0.9991224,0.00001776713,0.000390773,0.00001188833,0.00000186139,0.00000534464,0.0003719935,0.000003054976,0.00007485307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001446679,"threshold_uncertainty_score":0.002876461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02256116275161324,"score_gpt":0.2816231978053977,"score_spread":0.2590620350537844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}