{"id":"W2902828566","doi":"10.1021/acs.jproteome.8b00351","title":"Metabolic Signatures of Cystic Fibrosis Identified in Dried Blood Spots For Newborn Screening Without Carrier Identification","year":2018,"lang":"en","type":"article","venue":"Journal of Proteome Research","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Newborn Screening Ontario; Children's Hospital of Eastern Ontario; University of Ottawa; McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; Cystic Fibrosis Canada; Genome Canada","keywords":"Cystic fibrosis; Newborn screening; Cystic fibrosis transmembrane conductance regulator; Sweat test; Dried blood spot; Medicine; Internal medicine; Acetylcarnitine; Metabolomics; Biomarker; Metabolite; Meconium Ileus; Carnitine; Gastroenterology; Endocrinology; Chemistry; Meconium; Biochemistry; Biology; Chromatography; Fetus; Pregnancy; Pediatrics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003112268,0.0003386037,0.0002295531,0.001269888,0.00032052,0.000403789,0.0001614086,0.0005133274,0.001595509],"category_scores_gemma":[0.0006227102,0.000134958,0.0001672371,0.0008841383,0.0002013825,0.0001203399,0.0002583845,0.0002641981,0.0004404373],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000180259,"about_ca_system_score_gemma":0.0002505052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001345736,"about_ca_topic_score_gemma":0.002136735,"domain_scores_codex":[0.999795,0.00003215738,0.00001679227,0.00004979483,0.0000745728,0.00003166073],"domain_scores_gemma":[0.999826,0.00003529293,0.00005243364,0.00001678895,0.00003873905,0.00003079203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002014082,0.00009192887,0.05490544,0.0003068243,0.0001518243,0.002853322,0.0002602835,0.0002122502,0.8939263,0.0003053337,0.001744317,0.04322811],"study_design_scores_gemma":[0.0000450195,0.000640241,0.5681282,0.0001100351,0.0002299528,0.02345962,0.0004159756,0.003352039,0.3930328,0.0005686791,0.009967288,0.00005023174],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842041,0.003563492,0.003991399,0.0002685008,0.00008853414,0.00005839418,0.005153853,0.0002657181,0.002405994],"genre_scores_gemma":[0.9834229,0.001284155,0.01060576,0.0002453141,0.00002372747,0.00004779473,0.002800278,0.00003425604,0.00153588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001595509,"threshold_uncertainty_score":0.005337477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05623269105415057,"score_gpt":0.4128441975976315,"score_spread":0.3566115065434809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}