{"id":"W2902828566","doi":"10.1021/acs.jproteome.8b00351","title":"Metabolic Signatures of Cystic Fibrosis Identified in Dried Blood Spots For Newborn Screening Without Carrier Identification","year":2018,"lang":"en","type":"article","venue":"Journal of Proteome Research","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Newborn Screening Ontario; Children's Hospital of Eastern Ontario; University of Ottawa; McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; Cystic Fibrosis Canada; Genome Canada","keywords":"Cystic fibrosis; Newborn screening; Cystic fibrosis transmembrane conductance regulator; Sweat test; Dried blood spot; Medicine; Internal medicine; Acetylcarnitine; Metabolomics; Biomarker; Metabolite; Meconium Ileus; Carnitine; Gastroenterology; Endocrinology; Chemistry; Meconium; Biochemistry; Biology; Chromatography; Fetus; Pregnancy; Pediatrics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.007557515,0.0001767691,0.0007500679,0.001860695,0.0001710661,0.0001080451,0.0005004258,0.0001618321,0.0001180774],"category_scores_gemma":[0.01120133,0.0001444213,0.0002253562,0.001543677,0.000591472,0.0004491177,0.0001306845,0.0009625272,0.000007651282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001080032,"about_ca_system_score_gemma":0.0007247994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000104053,"about_ca_topic_score_gemma":0.00005015591,"domain_scores_codex":[0.9948649,0.0004694222,0.001216859,0.0003435837,0.002380472,0.0007247251],"domain_scores_gemma":[0.9936881,0.0008501165,0.0005377781,0.0004704395,0.004101231,0.0003523142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004922197,0.0002534234,0.006279981,0.0005937181,0.0002002452,0.00003564212,0.0004533017,0.0000287174,0.9768682,0.0001001589,0.000383753,0.00988067],"study_design_scores_gemma":[0.005396882,0.00238332,0.1886139,0.001521099,0.0001596366,0.00010576,0.0005585643,0.0009692226,0.7949996,0.002105256,0.003030632,0.0001560934],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9724166,0.002952355,0.02116891,0.0006490162,0.0001453646,0.002500414,0.00004740508,0.00001202113,0.0001079342],"genre_scores_gemma":[0.9242007,0.00009618464,0.07416749,0.000008747498,0.0006314956,0.0001158532,0.00000837228,0.00004451594,0.0007266233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.182334,"threshold_uncertainty_score":0.9971277,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05623269105415057,"score_gpt":0.4128441975976315,"score_spread":0.3566115065434809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}