{"id":"W2902840085","doi":"10.1128/mbio.02377-18","title":"The Monothiol Glutaredoxin Grx4 Regulates Iron Homeostasis and Virulence in Cryptococcus neoformans","year":2018,"lang":"en","type":"article","venue":"mBio","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; University of British Columbia; Ministry of Science, ICT and Future Planning; National Research Foundation; National Institutes of Health; National Science Foundation; Government of Canada; National Research Foundation of Korea; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Glutaredoxin; Cryptococcus neoformans; Virulence; Mutant; Biology; Transcriptome; Virulence factor; Phenotype; Cell biology; Homeostasis; Microbiology; Gene; Genetics; Gene expression; Thioredoxin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009920777,0.0001728871,0.00009922707,0.0001751799,0.0001195686,0.0001699547,0.0001228316,0.0001753487,0.0003494451],"category_scores_gemma":[0.00007608434,0.00007306348,0.0001156138,0.00008262919,0.000223759,0.00008569587,0.000148612,0.0002043266,0.0001041674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004142182,"about_ca_system_score_gemma":0.000176323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0016661,"about_ca_topic_score_gemma":0.001985987,"domain_scores_codex":[0.9999344,0.00001120416,0.00000391549,0.00001075996,0.00001760812,0.00002196968],"domain_scores_gemma":[0.9999498,0.000007350864,0.00001779696,0.000005008801,0.000006223806,0.00001385813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009960965,0.00001276388,0.0007706404,0.000007744076,0.000001454926,0.00004873634,0.000008610657,0.00004924766,0.998304,0.00004065333,0.00001461662,0.0006418721],"study_design_scores_gemma":[0.00002262569,0.0002332129,0.05002521,0.000006196308,0.00001467936,0.000410878,0.0001063702,0.002159261,0.9455757,0.0001343481,0.001305152,0.000006424237],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984508,0.0004872447,0.0005753146,0.00005760706,0.00000559246,0.000005951411,0.0000563683,0.00001708408,0.000344153],"genre_scores_gemma":[0.9980046,0.0002128475,0.0006152648,0.00002692217,0.000001900864,0.000004062857,0.00006962318,0.000003355479,0.00106136],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0016661,"threshold_uncertainty_score":0.003312886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01031474137658455,"score_gpt":0.2616365498117602,"score_spread":0.2513218084351756,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}