{"id":"W2902844274","doi":"10.1016/s1470-2045(18)30621-1","title":"Use of letrozole after aromatase inhibitor-based therapy in postmenopausal breast cancer (NRG Oncology/NSABP B-42): a randomised, double-blind, placebo-controlled, phase 3 trial","year":2018,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":163,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"Korea Health Industry Development Institute; Ministry of Health and Welfare; National Cancer Institute; U.S. Department of Health and Human Services; National Institutes of Health; U.S. Public Health Service; Novartis Pharmaceuticals Corporation","keywords":"Medicine; Letrozole; Aromatase inhibitor; Internal medicine; Breast cancer; Tamoxifen; Placebo; Oncology; Clinical endpoint; Interim analysis; Cancer; Gynecology; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00120898,0.0003432864,0.00105149,0.0001239738,0.0001016503,0.00002504228,0.0003708408,0.0006387372,0.000130792],"category_scores_gemma":[0.00006918103,0.0002224508,0.0002243364,0.0002064742,0.0006206202,0.00001398642,0.0000997858,0.0004191717,0.00002483211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001232285,"about_ca_system_score_gemma":0.0007291837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000210102,"about_ca_topic_score_gemma":0.0002914774,"domain_scores_codex":[0.9971168,0.0009924257,0.0006350944,0.0004703375,0.000181654,0.0006037012],"domain_scores_gemma":[0.9984257,0.0002939401,0.0003953751,0.000614814,0.0001452027,0.0001249307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7866093,0.001291315,0.0001954446,0.00001083675,0.0003241491,0.00005610084,0.000110821,0.00005425546,0.2039669,0.00001413532,0.002675134,0.004691622],"study_design_scores_gemma":[0.8859926,0.01234179,0.0001165524,0.00003229408,0.0001449302,0.00006490253,0.00002893872,0.0001556963,0.07714812,0.00001452655,0.02369515,0.0002644777],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919772,0.001539931,0.00002528053,0.001988993,0.0007558109,0.003062477,0.0002019683,0.0000233547,0.0004249528],"genre_scores_gemma":[0.9933754,0.0005831491,0.0001708942,0.001748258,0.002389724,0.001475168,0.0001197485,0.00004285209,0.00009476877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1268188,"threshold_uncertainty_score":0.9071279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04278072334570308,"score_gpt":0.3548242458836685,"score_spread":0.3120435225379654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}