{"id":"W2902844274","doi":"10.1016/s1470-2045(18)30621-1","title":"Use of letrozole after aromatase inhibitor-based therapy in postmenopausal breast cancer (NRG Oncology/NSABP B-42): a randomised, double-blind, placebo-controlled, phase 3 trial","year":2018,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":163,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"Korea Health Industry Development Institute; Ministry of Health and Welfare; National Cancer Institute; U.S. Department of Health and Human Services; National Institutes of Health; U.S. Public Health Service; Novartis Pharmaceuticals Corporation","keywords":"Medicine; Letrozole; Aromatase inhibitor; Internal medicine; Breast cancer; Tamoxifen; Placebo; Oncology; Clinical endpoint; Interim analysis; Cancer; Gynecology; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001225187,0.001752412,0.003266962,0.0005575927,0.0004472202,0.0009807321,0.0008304901,0.002532772,0.00635073],"category_scores_gemma":[0.001421486,0.0007182545,0.001626205,0.0004872032,0.001303318,0.00114161,0.0003589634,0.00306537,0.001259821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006495861,"about_ca_system_score_gemma":0.0008633392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001117433,"about_ca_topic_score_gemma":0.002650723,"domain_scores_codex":[0.9995661,0.0002071113,0.00002373566,0.00008093389,0.00003714208,0.00008489712],"domain_scores_gemma":[0.9994689,0.0001561073,0.00009036545,0.00004850698,0.00002777972,0.0002085194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9845852,0.002166381,0.0002035416,0.0004185941,0.0005492672,0.00002890448,0.0000342444,0.000159786,0.00192443,0.00006302269,0.0005732295,0.009293291],"study_design_scores_gemma":[0.9614409,0.03634481,0.0008059439,0.00002103843,0.0002969279,0.00001980687,0.00001667279,0.0001368881,0.0002513425,0.0001080379,0.0005470462,0.00001060605],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9784828,0.01051351,0.0007746568,0.001397356,0.0009512787,0.002963178,0.001564493,0.0003050362,0.003047846],"genre_scores_gemma":[0.981152,0.005883274,0.001107881,0.001564373,0.0005081419,0.002452118,0.00140217,0.00004174881,0.005888491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00635073,"threshold_uncertainty_score":0.0212453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04278072334570308,"score_gpt":0.3548242458836685,"score_spread":0.3120435225379654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}