{"id":"W2902865577","doi":"10.3390/cancers10120477","title":"Screening BRCA1 and BRCA2 Mutation Carriers for Breast Cancer","year":2018,"lang":"en","type":"review","venue":"Cancers","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Mammography; Breast cancer; Observational study; Oncology; Magnetic resonance imaging; Stage (stratigraphy); Breast cancer screening; Cancer; Internal medicine; Gynecology; Radiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001544387,0.0003506686,0.0005366342,0.00008758721,0.0001626795,0.00004885047,0.0002220066,0.0003871581,0.00004879958],"category_scores_gemma":[0.00003974598,0.0003438506,0.0002437775,0.0001553625,0.0002273617,0.000005596073,0.00007550747,0.0001167608,0.000002584046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009728934,"about_ca_system_score_gemma":0.002588668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001295009,"about_ca_topic_score_gemma":0.000199533,"domain_scores_codex":[0.9984949,0.00003605062,0.0003204647,0.0007134929,0.0001135482,0.0003215106],"domain_scores_gemma":[0.9990444,0.00002522543,0.0002799398,0.0003618514,0.0001677709,0.0001208136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002598764,0.000001439799,0.000004897266,0.002571616,0.0004489909,9.11435e-7,0.00005773909,0.00008706417,0.00003060458,0.000008750902,0.01786107,0.9789009],"study_design_scores_gemma":[0.0003422676,0.0000670593,0.000008249901,0.001518913,0.0005322553,0.00006830886,0.00006253445,0.00005078003,0.0001243,0.00001217913,0.9968014,0.0004116897],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008489069,0.9940905,0.001914206,0.00003980102,0.0008256095,0.000833668,0.002073751,0.00001744807,0.0001201134],"genre_scores_gemma":[0.000158989,0.9942047,0.001296226,0.0001809075,0.001779084,0.001107009,0.0005717204,0.0001084618,0.0005928751],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9789404,"threshold_uncertainty_score":0.9999014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03352845659242609,"score_gpt":0.3480021272252624,"score_spread":0.3144736706328363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}