{"id":"W2902881290","doi":"10.1534/genetics.118.301733","title":"Coupling of Human Rhodopsin to a Yeast Signaling Pathway Enables Characterization of Mutations Associated with Retinal Disease","year":2018,"lang":"en","type":"article","venue":"Genetics","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Rhodopsin; Biology; G protein-coupled receptor; Retinitis pigmentosa; Genetics; Arrestin; Phenotype; Retinal degeneration; Mutation; Mutant; Model organism; Signal transduction; Computational biology; Cell biology; Retinal; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001480727,0.00009684785,0.000124111,0.00004600271,0.00007813015,0.00001152204,0.00009683293,0.00006017387,0.00004328194],"category_scores_gemma":[0.00005798906,0.00009311677,0.00003788985,0.0001250039,0.00006507301,0.000002187052,0.00003871894,0.00002872054,0.000001128091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007725181,"about_ca_system_score_gemma":0.00007652133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003278,"about_ca_topic_score_gemma":0.00001371512,"domain_scores_codex":[0.9992829,0.00002031645,0.0002271494,0.0001841792,0.000145007,0.0001404553],"domain_scores_gemma":[0.9992414,0.000005663445,0.000170866,0.0001636713,0.0003362318,0.0000822084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005007704,0.00004672677,0.002091999,0.00001749744,0.00002970282,6.532983e-7,0.0001656853,0.0009030043,0.9965096,0.00005479487,0.000004534742,0.0001257142],"study_design_scores_gemma":[0.0002139837,0.0006014075,0.003842589,0.0001049998,0.00003131031,4.943402e-7,0.0000867702,0.0006135755,0.9942615,0.00003590216,0.00009212534,0.0001153561],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9779487,0.00003171526,0.02169906,0.00001095144,0.00004009962,0.0001459654,0.0000909213,0.000006136056,0.00002646536],"genre_scores_gemma":[0.9976234,0.000004695002,0.001750443,0.00002390962,0.0001275962,0.000008045936,0.0003657089,0.00002177206,0.00007445225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01994861,"threshold_uncertainty_score":0.3797192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01403242930961581,"score_gpt":0.2419017396174858,"score_spread":0.2278693103078699,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}