{"id":"W2902933008","doi":"10.1016/j.cllc.2018.11.012","title":"Phase 1b/2 Randomized Study of MEDI-575 in Combination With Carboplatin Plus Paclitaxel Versus Carboplatin Plus Paclitaxel Alone in Adult Patients With Previously Untreated Advanced Non–Small-Cell Lung Cancer","year":2018,"lang":"en","type":"article","venue":"Clinical Lung Cancer","topic":"Lung Cancer Research Studies","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Eli Lilly Japan; Pfizer Japan; Genentech; MSD K.K.; Ono Pharmaceutical; Stiftelsen för Kunskaps- och Kompetensutveckling; Exelixis; Taiho Pharmaceutical; North Carolina GlaxoSmithKline Foundation; Novartis; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; Bayer Corporation; Takeda Pharmaceutical Company; AbbVie; MedImmune; Merck; GlaxoSmithKline; Celgene; Bayer","keywords":"Carboplatin; Paclitaxel; Medicine; Lung cancer; Oncology; Internal medicine; Chemotherapy; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001716549,0.0007486384,0.003296433,0.0004563994,0.0001369181,0.00003155514,0.0003756133,0.0003177202,0.0001171479],"category_scores_gemma":[0.001971957,0.0005306622,0.0002119785,0.001516947,0.0009945256,0.0002569531,0.0002181926,0.00115135,0.000003396371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002582864,"about_ca_system_score_gemma":0.002130569,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.01461125,"about_ca_topic_score_gemma":0.07450001,"domain_scores_codex":[0.9927621,0.0009190505,0.002308408,0.001374565,0.001525315,0.001110532],"domain_scores_gemma":[0.9933907,0.002208231,0.001075741,0.0009369412,0.00191817,0.0004702526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4407849,0.007770297,0.5360853,0.0009338236,0.001522618,0.0001095843,0.008718594,0.0004219704,0.00004205122,0.000007130697,0.0004280182,0.003175696],"study_design_scores_gemma":[0.8716496,0.01517999,0.08720984,0.003442877,0.001775736,8.154077e-7,0.001841157,0.01803195,0.0002232272,0.0000054814,0.00001818176,0.0006211232],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9817011,0.00252698,0.00004453123,0.0004454444,0.0006946835,0.01357554,0.0001187803,0.00008143064,0.000811515],"genre_scores_gemma":[0.993487,0.001288588,0.0003618506,0.0001834594,0.0002785774,0.003790555,0.0001066297,0.0001324117,0.0003709331],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4488755,"threshold_uncertainty_score":0.9997145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02561469216365942,"score_gpt":0.4055740958390569,"score_spread":0.3799594036753975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}