{"id":"W2902933008","doi":"10.1016/j.cllc.2018.11.012","title":"Phase 1b/2 Randomized Study of MEDI-575 in Combination With Carboplatin Plus Paclitaxel Versus Carboplatin Plus Paclitaxel Alone in Adult Patients With Previously Untreated Advanced Non–Small-Cell Lung Cancer","year":2018,"lang":"en","type":"article","venue":"Clinical Lung Cancer","topic":"Lung Cancer Research Studies","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Eli Lilly Japan; Pfizer Japan; Genentech; MSD K.K.; Ono Pharmaceutical; Stiftelsen för Kunskaps- och Kompetensutveckling; Exelixis; Taiho Pharmaceutical; North Carolina GlaxoSmithKline Foundation; Novartis; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; Bayer Corporation; Takeda Pharmaceutical Company; AbbVie; MedImmune; Merck; GlaxoSmithKline; Celgene; Bayer","keywords":"Carboplatin; Paclitaxel; Medicine; Lung cancer; Oncology; Internal medicine; Chemotherapy; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002450362,0.003054048,0.005245819,0.0007686539,0.0006741825,0.001547807,0.001672082,0.002097817,0.01003372],"category_scores_gemma":[0.001751168,0.001462845,0.002923289,0.0007847052,0.002053367,0.00178303,0.0007277892,0.005849861,0.001604502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001620053,"about_ca_system_score_gemma":0.002334056,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002521225,"about_ca_topic_score_gemma":0.0059737,"domain_scores_codex":[0.9990813,0.0004837997,0.00004813149,0.0001625585,0.0000499126,0.0001743447],"domain_scores_gemma":[0.9989337,0.0002230531,0.0002052675,0.0000992554,0.00006086614,0.000477847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9792213,0.01004792,0.0004158159,0.0002037754,0.0004974709,0.00002247085,0.000032222,0.0002766875,0.002003594,0.00006820969,0.0005933691,0.006617122],"study_design_scores_gemma":[0.9256861,0.07206287,0.001036512,0.00001017935,0.000309136,0.00001601874,0.0000161111,0.0001776741,0.0002361215,0.00006365465,0.000376011,0.000009693128],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843948,0.003264524,0.0007339176,0.001181632,0.0007465508,0.005091321,0.001983264,0.0001616747,0.002442314],"genre_scores_gemma":[0.9723871,0.004062295,0.003062678,0.002065422,0.001110053,0.007344507,0.003384063,0.00008255123,0.006501221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01003372,"threshold_uncertainty_score":0.03356618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02561469216365942,"score_gpt":0.4055740958390569,"score_spread":0.3799594036753975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}