{"id":"W2902951428","doi":"10.1007/s12192-018-0948-4","title":"Function, evolution, and structure of J-domain proteins","year":2018,"lang":"en","type":"article","venue":"Cell Stress and Chaperones","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":182,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; University of Toronto","funders":"National Institute of General Medical Sciences; Medical Research Council; Motor Neurone Disease Association","keywords":"Chaperone (clinical); Co-chaperone; Protein folding; Computational biology; Hsp70; Biology; Domain (mathematical analysis); Function (biology); Proteostasis; Three-domain system; Cell biology; Heat shock protein; Genetics; Medicine; Gene; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004412153,0.00009026397,0.00008878973,0.00002884092,0.0001116079,0.00001248181,0.00006308231,0.0001043239,0.00006145294],"category_scores_gemma":[0.00001518504,0.00007588656,0.00001500451,0.00004780103,0.0002716539,0.000003676317,0.0001041324,0.00004876153,0.000001077974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004001783,"about_ca_system_score_gemma":0.00003306619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005399066,"about_ca_topic_score_gemma":0.0001241962,"domain_scores_codex":[0.999393,0.00003182926,0.0001035523,0.0002254413,0.00009324781,0.0001528791],"domain_scores_gemma":[0.9996195,0.000003356139,0.00002998898,0.0001692663,0.0001076205,0.00007020855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006680388,0.00002489727,0.008307941,0.00009670261,0.00001316667,3.289962e-7,0.00008084039,6.450443e-7,0.9895715,0.0002955996,0.0001019113,0.001439643],"study_design_scores_gemma":[0.0004232872,0.0007695137,0.02239065,0.00002205934,0.0000068605,0.000004632111,0.0002920526,0.00001690702,0.9694661,0.000609863,0.005878437,0.0001196672],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956445,0.002130292,0.001462872,0.0000568527,0.00003381549,0.0001928076,0.00004671773,0.000004533997,0.0004275969],"genre_scores_gemma":[0.9989067,0.0001320282,0.0003462652,0.00001642972,0.0002098427,0.000009129753,0.00002339734,0.00001055747,0.0003456105],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02010545,"threshold_uncertainty_score":0.3094564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005770368685438984,"score_gpt":0.2263084766959492,"score_spread":0.2205381080105102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}