{"id":"W2902954276","doi":"10.1182/blood-2018-99-119740","title":"Modeling Targeted Lymphodepletion with Radiolabeled CD45 Antibody As a Promising Preparative Regimen Prior to Adoptive Cell Therapy or CAR-T","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Immune system; Medicine; Adoptive cell transfer; Immunology; Cytokine release syndrome; T cell; Bone marrow; Cancer research; Myeloid; Haematopoiesis; Cell therapy; Tumor microenvironment; Transplantation; Stem cell; Chimeric antigen receptor; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005929567,0.0002085044,0.0001070641,0.0001018642,0.00006677851,0.0002535634,0.0002157914,0.0001714692,0.001010081],"category_scores_gemma":[0.00006616821,0.00008285983,0.0001372502,0.00008685821,0.0000934617,0.0001217611,0.00008394432,0.0002038464,0.0001880144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002829376,"about_ca_system_score_gemma":0.0002029974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009214511,"about_ca_topic_score_gemma":0.000778941,"domain_scores_codex":[0.9999679,0.000005696435,0.000001044148,0.0000096207,0.000008222141,0.000007510644],"domain_scores_gemma":[0.9999789,0.000006311802,0.00000744729,0.000001628712,0.000002110846,0.000003629038],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0002628364,0.0002885378,0.0008251107,0.0001041837,0.00001265817,0.0001072863,0.00002366782,0.1099855,0.8790529,0.001220549,0.0002231781,0.007893663],"study_design_scores_gemma":[0.00006507446,0.001668429,0.001368289,0.00001220155,0.00003616506,0.00009579887,0.00001892179,0.3383366,0.6543279,0.0003700681,0.003690135,0.00001039771],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9294943,0.001334701,0.06439545,0.000148144,0.00004210631,0.0001526988,0.0002702678,0.0001900647,0.003972256],"genre_scores_gemma":[0.9871546,0.0004656319,0.01082208,0.00002436026,0.000004233946,0.00006544989,0.0001017398,0.00001327559,0.00134857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001010081,"threshold_uncertainty_score":0.003379107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02919151571254698,"score_gpt":0.3330513123574293,"score_spread":0.3038597966448823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}