{"id":"W2902954927","doi":"10.1002/jbm4.10128","title":"Promoter Cre‐Specific Genotyping Assays for Authentication of Cre‐Driver Mouse Lines","year":2018,"lang":"en","type":"article","venue":"JBMR Plus","topic":"Molecular Biology Techniques and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Aging; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute on Aging; National Institutes of Health","keywords":"Cre recombinase; Computational biology; Biology; Transgene; Gene knockin; Gene; Genotyping; Function (biology); Gene knockout; Cre-Lox recombination; Cell culture; Gene targeting; Genetically modified mouse; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005984734,0.002753494,0.001665929,0.006355715,0.00101154,0.001267917,0.002021169,0.002347276,0.007757375],"category_scores_gemma":[0.00977339,0.002000836,0.001795871,0.002367771,0.001151253,0.001079326,0.001214895,0.003612201,0.01451355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005500593,"about_ca_system_score_gemma":0.0009650766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000471802,"about_ca_topic_score_gemma":0.002102643,"domain_scores_codex":[0.9891104,0.002434907,0.0020726,0.002623632,0.002874832,0.0008836247],"domain_scores_gemma":[0.98998,0.002985554,0.002199413,0.001882012,0.002376868,0.0005760693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001454955,0.0001775773,0.000826489,0.0002628537,0.00003512415,0.00009160145,0.0001179352,0.0001873237,0.9883562,0.0006379231,0.000549234,0.008612332],"study_design_scores_gemma":[0.0000673661,0.0008004421,0.004929094,0.0001510517,0.000223136,0.0006622698,0.0000584643,0.002255629,0.9727568,0.0004487608,0.01757562,0.00007137052],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.07086512,0.001800406,0.9025247,0.0002132669,0.000318601,0.005966546,0.006473238,0.005620709,0.006217426],"genre_scores_gemma":[0.09722999,0.003097823,0.8500856,0.0004600425,0.00007942407,0.01148632,0.02512811,0.002232525,0.01020022],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.007757375,"threshold_uncertainty_score":0.03165072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01825090628568931,"score_gpt":0.2931914155416858,"score_spread":0.2749405092559964,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}