{"id":"W2903018244","doi":"10.3233/jad-180482","title":"Next Generation Sequencing Analysis in Early Onset Dementia Patients","year":2018,"lang":"en","type":"article","venue":"Journal of Alzheimer s Disease","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Ministero della Salute; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Dementia; Medicine; Psychology; Internal medicine; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001878328,0.00009514559,0.0001297159,0.0001656145,0.00005637006,0.00006580678,0.0001288432,0.0000428041,0.00006541228],"category_scores_gemma":[0.00007392306,0.00008745838,0.0002047672,0.0002103695,0.00003381218,0.00002972302,0.00004485974,0.00005550307,0.000004795313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001653481,"about_ca_system_score_gemma":0.0001520814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002103209,"about_ca_topic_score_gemma":0.00002474146,"domain_scores_codex":[0.999107,0.00008162834,0.0003313747,0.0001478648,0.0001848223,0.0001473267],"domain_scores_gemma":[0.9991579,0.000003214072,0.0002253477,0.0001714183,0.0002267696,0.0002153336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003653768,0.0001683921,0.9546849,0.000004636843,0.001978425,0.00003182827,0.00007465384,0.0003359372,0.03365237,0.000005929387,0.001070264,0.007627332],"study_design_scores_gemma":[0.001098478,0.0004457567,0.9636995,0.00002575016,0.003170211,0.000002420317,0.0000307535,0.001154161,0.02909519,0.00006889122,0.0009645452,0.0002443221],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891512,0.00985885,0.0007093658,0.00004793601,0.0001243507,0.00007537885,0.00001552369,0.000001679691,0.00001567465],"genre_scores_gemma":[0.9986224,0.0002292129,0.0004516926,0.0002431497,0.0003891789,0.00000262723,0.00004762432,0.000009201398,0.000004917168],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009629638,"threshold_uncertainty_score":0.3566449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0359370964478725,"score_gpt":0.2780887149069722,"score_spread":0.2421516184590997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}