{"id":"W2903018244","doi":"10.3233/jad-180482","title":"Next Generation Sequencing Analysis in Early Onset Dementia Patients","year":2018,"lang":"en","type":"article","venue":"Journal of Alzheimer s Disease","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Ministero della Salute; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Dementia; Medicine; Psychology; Internal medicine; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006836698,0.0002758227,0.000271859,0.0008636671,0.0003089224,0.0004452263,0.0002066289,0.0004492636,0.0009219139],"category_scores_gemma":[0.001657501,0.0001036312,0.0002132168,0.0003952529,0.0001045864,0.00009591564,0.0002552472,0.0002251002,0.0003292199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000265001,"about_ca_system_score_gemma":0.0002083097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001126397,"about_ca_topic_score_gemma":0.001690608,"domain_scores_codex":[0.999665,0.00009502233,0.00004494169,0.00009272903,0.00006334066,0.00003888608],"domain_scores_gemma":[0.9994893,0.0002032671,0.0001079144,0.00003837802,0.0001052143,0.0000559201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001636791,0.0003132306,0.8576838,0.0002812622,0.0002289734,0.006259399,0.0009312599,0.001162565,0.05659892,0.0004303679,0.003175697,0.07129774],"study_design_scores_gemma":[0.0001864542,0.0008732755,0.9342787,0.0001490187,0.0002919563,0.0159487,0.0006207895,0.009363851,0.02287362,0.001891573,0.0134849,0.00003718643],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927028,0.001182086,0.003033193,0.0001371296,0.00002727827,0.00006964528,0.001373939,0.0000519309,0.001421921],"genre_scores_gemma":[0.9912339,0.0003917442,0.00541222,0.0003294663,0.00001675387,0.00009416594,0.002014815,0.0000157121,0.0004912968],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001126397,"threshold_uncertainty_score":0.003615618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0359370964478725,"score_gpt":0.2780887149069722,"score_spread":0.2421516184590997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}