{"id":"W2903047335","doi":"10.1242/dev.166876","title":"<i>C. elegans</i> PTEN and AMPK block neuroblast divisions by inhibiting a BMP-insulin-PP2A-MAPK pathway","year":2018,"lang":"en","type":"article","venue":"Development","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Office of Research Infrastructure Programs, National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; Protein phosphatase 2; Neuroblast; Caenorhabditis elegans; AMPK; Cell biology; Transcription factor; Signal transduction; Asymmetric cell division; Protein kinase A; PTEN; Regulator; Kinase; Phosphorylation; Phosphatase; Genetics; Cell division; Cell; PI3K/AKT/mTOR pathway; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009285106,0.0005201091,0.0001881738,0.0002748142,0.0002531639,0.0002583801,0.0003236984,0.0002171244,0.002381416],"category_scores_gemma":[0.00006848822,0.0001839948,0.0002472616,0.00009538644,0.0002968631,0.0001880567,0.0002472105,0.0005585989,0.000447945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004009079,"about_ca_system_score_gemma":0.0003193442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001166236,"about_ca_topic_score_gemma":0.003330633,"domain_scores_codex":[0.9998864,0.00001126013,0.00001272659,0.00002516471,0.0000359093,0.00002857846],"domain_scores_gemma":[0.9998955,0.00001106512,0.00003292679,0.000009113492,0.000007149647,0.00004436082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001791129,0.00005492964,0.0002007014,0.00003971127,0.00001043513,0.00006621074,0.000005782473,0.00008731694,0.9976087,0.0002759562,0.0001726375,0.001298516],"study_design_scores_gemma":[0.00003479535,0.000277193,0.002979945,0.000006673382,0.00001980051,0.0001994602,0.00001654336,0.001198197,0.9913237,0.00008417483,0.003854927,0.000004523431],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881697,0.001026339,0.002546672,0.0003395398,0.00009436916,0.00005179398,0.0005980541,0.0003892641,0.00678433],"genre_scores_gemma":[0.9861403,0.0007005126,0.004698511,0.0001353931,0.00001969664,0.00007330866,0.0005777919,0.0001053733,0.007549053],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002381416,"threshold_uncertainty_score":0.007966638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00636868620620398,"score_gpt":0.203018343886239,"score_spread":0.196649657680035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}