{"id":"W2903062212","doi":"10.1056/nejmoa1804980","title":"Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma","year":2018,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":4044,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Juravinski Hospital; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Novartis Pharmaceuticals Corporation","keywords":"Medicine; Cytokine release syndrome; Neutropenia; Internal medicine; Hematopoietic stem cell transplantation; Diffuse large B-cell lymphoma; Lymphoma; Refractory (planetary science); Transplantation; Gastroenterology; Febrile neutropenia; Rituximab; Clinical endpoint; Oncology; Phases of clinical research; Salvage therapy; Immunology; Immunotherapy; Chimeric antigen receptor; Chemotherapy; Clinical trial; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008851236,0.0003306315,0.0006732082,0.0002384601,0.0001221118,0.0002808762,0.000277382,0.0002885225,0.0009996521],"category_scores_gemma":[0.0005745145,0.00009088591,0.0002405087,0.0002857137,0.0002635889,0.0001899134,0.0002117684,0.0004515481,0.0002302939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003062808,"about_ca_system_score_gemma":0.0003584277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003231988,"about_ca_topic_score_gemma":0.0008329755,"domain_scores_codex":[0.9997131,0.0001589986,0.00002552225,0.00003211386,0.0000412912,0.00002899694],"domain_scores_gemma":[0.9996327,0.0001104104,0.0001056634,0.00001945648,0.00002904395,0.0001026472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.09165528,0.007311597,0.1403761,0.002710366,0.0009462834,0.004904231,0.0006895621,0.004727624,0.09867002,0.0005171694,0.004721222,0.6427705],"study_design_scores_gemma":[0.06452425,0.4703822,0.3783335,0.0004392911,0.001174264,0.01772509,0.0004215865,0.006315625,0.02938424,0.0004779028,0.03075245,0.00006968524],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908443,0.007535293,0.0002468318,0.0001107997,0.00001669981,0.0001269451,0.00008198217,0.0000355441,0.001001597],"genre_scores_gemma":[0.9971814,0.001834823,0.0003535141,0.0001367298,0.00003650991,0.0000611486,0.0001969471,0.000004376681,0.0001944977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009996521,"threshold_uncertainty_score":0.004681051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02608030782430969,"score_gpt":0.3167913150251551,"score_spread":0.2907110072008454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}