{"id":"W2903068554","doi":"10.1093/toxsci/kfy285","title":"Transient Receptor Potential Ion Channels Mediate Adherens Junctions Dysfunction in a Toluene Diisocyanate-Induced Murine Asthma Model","year":2018,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; St. Joseph’s Healthcare Hamilton","funders":"National Key Research and Development Program of China; National Postdoctoral Program for Innovative Talents; China Postdoctoral Science Foundation; Natural Science Foundation of Guangdong Province; National Natural Science Foundation of China","keywords":"Toluene diisocyanate; Adherens junction; Transient receptor potential channel; Neutrophilia; Chemistry; Bosentan; GSK-3; Pharmacology; Immunology; Medicine; Phosphorylation; Receptor; Cadherin; Biochemistry; Endothelin receptor; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006973799,0.0002467172,0.0002773513,0.000247656,0.0007760219,0.0001155523,0.0004649122,0.000238647,0.001608725],"category_scores_gemma":[0.0003585675,0.0001664412,0.0001195457,0.001323328,0.0008925214,0.0003762472,0.0001189832,0.0002859384,0.0003119005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001143381,"about_ca_system_score_gemma":0.00009010163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004955782,"about_ca_topic_score_gemma":0.0001106949,"domain_scores_codex":[0.9970069,0.0002413986,0.0004154937,0.000916974,0.0006765063,0.0007427529],"domain_scores_gemma":[0.9993493,0.00009464217,0.0001283244,0.0001277016,0.00006320477,0.00023682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009273959,0.0004330641,0.00001875876,0.000004281122,0.00000191343,0.000008788468,0.0004076379,0.007334674,0.9864476,0.00101337,0.0007533837,0.003483801],"study_design_scores_gemma":[0.001090609,0.003405101,0.000773953,0.00003489774,0.000008236313,0.00002369194,0.0003792564,0.2004984,0.7892975,0.002622753,0.001366944,0.0004986121],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870905,0.00001190701,0.001649899,0.002491603,0.005877521,0.0004290538,0.00001070755,0.000159648,0.002279161],"genre_scores_gemma":[0.9974889,0.00005976736,0.000235167,0.0006597944,0.0007311271,0.00007418032,0.000002449952,0.00001050911,0.0007381283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1971501,"threshold_uncertainty_score":0.9993039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07652924635482528,"score_gpt":0.3027620029375312,"score_spread":0.2262327565827059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}