{"id":"W2903068554","doi":"10.1093/toxsci/kfy285","title":"Transient Receptor Potential Ion Channels Mediate Adherens Junctions Dysfunction in a Toluene Diisocyanate-Induced Murine Asthma Model","year":2018,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; St. Joseph’s Healthcare Hamilton","funders":"National Key Research and Development Program of China; National Postdoctoral Program for Innovative Talents; China Postdoctoral Science Foundation; Natural Science Foundation of Guangdong Province; National Natural Science Foundation of China","keywords":"Toluene diisocyanate; Adherens junction; Transient receptor potential channel; Neutrophilia; Chemistry; Bosentan; GSK-3; Pharmacology; Immunology; Medicine; Phosphorylation; Receptor; Cadherin; Biochemistry; Endothelin receptor; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002776596,0.0007134036,0.000492032,0.0007107107,0.0002704521,0.0002586761,0.0003943556,0.0007181858,0.001855176],"category_scores_gemma":[0.0001013313,0.0002931137,0.0006762965,0.0002761026,0.0003874821,0.0003818896,0.0002612807,0.001576379,0.0004441917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004230643,"about_ca_system_score_gemma":0.0002913106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006461633,"about_ca_topic_score_gemma":0.001093647,"domain_scores_codex":[0.999648,0.00006239763,0.00003229382,0.00006209785,0.0001031016,0.00009211004],"domain_scores_gemma":[0.9998748,0.000007074196,0.00004632441,0.00001380293,0.00001242452,0.00004557365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008464918,0.0006138592,0.0006178575,0.00008620919,0.00001739748,0.0002597984,0.00003641641,0.0001472988,0.9949948,0.0001590509,0.0001411906,0.002079568],"study_design_scores_gemma":[0.0004665081,0.01048937,0.02524377,0.00005776028,0.000167969,0.001689951,0.0001607209,0.004959734,0.9514892,0.0003423024,0.004907035,0.00002577466],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908301,0.002410481,0.003471802,0.0003730067,0.00009579788,0.0001846359,0.0005199693,0.0002037181,0.001910529],"genre_scores_gemma":[0.990803,0.001944605,0.001933689,0.0001746465,0.00003712461,0.0003139386,0.0006271055,0.00001886197,0.004147051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001855176,"threshold_uncertainty_score":0.006206155,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07652924635482528,"score_gpt":0.3027620029375312,"score_spread":0.2262327565827059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}