{"id":"W2903080657","doi":"10.1038/s41467-018-07666-0","title":"Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice","year":2018,"lang":"en","type":"article","venue":"Nature Communications","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":143,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; National Institute on Aging; National Institutes of Health","keywords":"LRP1; Parabiosis; Cell biology; Bone healing; Bone marrow; Stromal cell; Macrophage; Biology; Secretion; Immunology; Medicine; Cancer research; LDL receptor; Lipoprotein; Endocrinology; Anatomy; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002868049,0.0004782118,0.0002925433,0.0008303666,0.0002411403,0.0003677788,0.0002599682,0.0004302176,0.0010701],"category_scores_gemma":[0.0001197459,0.0003664425,0.0003966421,0.0002144882,0.0004110842,0.0003482243,0.0003662691,0.0008613376,0.0005566372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003090143,"about_ca_system_score_gemma":0.000226473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002813814,"about_ca_topic_score_gemma":0.0007346888,"domain_scores_codex":[0.9998079,0.00002184575,0.00001933888,0.0000505587,0.00005151499,0.00004891828],"domain_scores_gemma":[0.9996789,0.00002214564,0.0001348966,0.00003053654,0.00002171458,0.0001118841],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000129363,0.00001941623,0.0003427644,0.00001199044,0.000002577732,0.00004593581,0.00001394583,0.00001537554,0.9983023,0.00008429949,0.0000268421,0.001005033],"study_design_scores_gemma":[0.00004534341,0.0005830504,0.01211319,0.00001237956,0.00002831922,0.00054199,0.00005421939,0.0004117046,0.9823841,0.000161145,0.003654949,0.000009595441],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872668,0.001641042,0.007977631,0.0002769109,0.00004394141,0.00005249988,0.0007909726,0.0003770555,0.001573131],"genre_scores_gemma":[0.9755781,0.002064151,0.01091402,0.0002649615,0.00004047136,0.0001534557,0.00115164,0.0001753893,0.009657698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0010701,"threshold_uncertainty_score":0.003579855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03440626539427155,"score_gpt":0.3095088328084183,"score_spread":0.2751025674141467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}