{"id":"W2903094977","doi":"10.1016/j.diabet.2018.11.004","title":"Clinical relevance of pharmacokinetic and pharmacodynamic profiles of insulin degludec (100, 200 U/mL) and insulin glargine (100, 300 U/mL) – a review of evidence and clinical interpretation","year":2018,"lang":"en","type":"review","venue":"Diabetes & Metabolism","topic":"Diabetes Management and Research","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Insulin degludec; Insulin glargine; Insulin; Pharmacodynamics; Medicine; Pharmacokinetics; Internal medicine; Endocrinology; Basal (medicine); Pharmacology; Hypoglycemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003480309,0.0011031,0.004889664,0.002170247,0.0001785978,0.002018962,0.001483312,0.001636464,0.003583887],"category_scores_gemma":[0.007753735,0.0005430047,0.003863065,0.002569571,0.0006399326,0.001353983,0.0006933794,0.001658267,0.0003822914],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007407587,"about_ca_system_score_gemma":0.001954912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001489741,"about_ca_topic_score_gemma":0.003336946,"domain_scores_codex":[0.9984481,0.0004438171,0.0005153806,0.0001983005,0.000341458,0.00005287234],"domain_scores_gemma":[0.9940473,0.004337532,0.001113562,0.00006957247,0.0003824189,0.00004966679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.001885275,0.0001287686,0.001423623,0.4591109,0.01092311,0.0003387533,0.0001161436,0.0004749269,0.001206305,0.00187378,0.007768779,0.5147497],"study_design_scores_gemma":[0.002291518,0.00191937,0.01837282,0.3905448,0.1085536,0.004256251,0.0006074103,0.0008204322,0.002306559,0.006841739,0.4632109,0.0002746681],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001770704,0.9994998,0.00002876487,0.0001072006,0.00003496022,0.000007269923,0.0000266373,9.652806e-7,0.0001173313],"genre_scores_gemma":[0.003859427,0.9953433,0.0001933492,0.000388534,0.00009159479,0.00001478052,0.00004664127,0.000001212291,0.00006104777],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004889664,"threshold_uncertainty_score":0.01840591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1151819002370611,"score_gpt":0.4694980418081827,"score_spread":0.3543161415711217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}