{"id":"W2903094977","doi":"10.1016/j.diabet.2018.11.004","title":"Clinical relevance of pharmacokinetic and pharmacodynamic profiles of insulin degludec (100, 200 U/mL) and insulin glargine (100, 300 U/mL) – a review of evidence and clinical interpretation","year":2018,"lang":"en","type":"review","venue":"Diabetes & Metabolism","topic":"Diabetes Management and Research","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Insulin degludec; Insulin glargine; Insulin; Pharmacodynamics; Medicine; Pharmacokinetics; Internal medicine; Endocrinology; Basal (medicine); Pharmacology; Hypoglycemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.006680765,0.0007115872,0.006003584,0.0006116483,0.0000471164,0.00002517888,0.0004969535,0.0004314514,0.0001382068],"category_scores_gemma":[0.005617799,0.0004992947,0.0007197605,0.0009884408,0.001761531,0.0002856913,0.0007067808,0.001032388,0.00001500871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002646138,"about_ca_system_score_gemma":0.0003078389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009450051,"about_ca_topic_score_gemma":0.000001189061,"domain_scores_codex":[0.9917469,0.001620154,0.004071228,0.001126846,0.0008536421,0.0005812189],"domain_scores_gemma":[0.9925555,0.003151051,0.002330122,0.0007597196,0.0008026351,0.0004009907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001215223,0.0003736102,0.00297724,0.2143982,0.001010657,0.000004450154,0.00002908876,3.57514e-8,0.00004598021,0.00002785264,0.0006422836,0.7803691],"study_design_scores_gemma":[0.004234539,0.00123391,0.01436927,0.3576303,0.017361,0.000006098026,0.0000113796,0.001429674,0.0001035818,0.0001035917,0.6027992,0.000717459],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04462808,0.9509603,0.00001581573,0.0001610852,0.0004933763,0.003426768,0.0001502001,0.00002992381,0.000134419],"genre_scores_gemma":[0.00348816,0.9935713,0.001503431,0.0002644744,0.0004549533,0.000142468,0.0001332386,0.00009261871,0.0003493909],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7796516,"threshold_uncertainty_score":0.9997458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1151819002370611,"score_gpt":0.4694980418081827,"score_spread":0.3543161415711217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}