{"id":"W2903132660","doi":"10.1182/blood-2018-99-113504","title":"Preclinical Activity of Novel MCL1 Inhibitor AZD5991 in Multiple Myeloma","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Calgary","funders":"","keywords":"MCL1; Cell culture; Apoptosis; Venetoclax; Stromal cell; Annexin A5; IC50; Programmed cell death; Molecular biology; Annexin; Chemistry; Cancer research; Medicine; Biology; Leukemia; Immunology; Biochemistry; Downregulation and upregulation; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002987201,0.000446862,0.0006514398,0.0004436856,0.0002904105,0.0003491507,0.0004933876,0.0004400862,0.001888557],"category_scores_gemma":[0.0001558323,0.0002115858,0.0003353441,0.0003273892,0.0001746058,0.0002826737,0.0002605181,0.001184014,0.0003703095],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004333315,"about_ca_system_score_gemma":0.0003554784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001026553,"about_ca_topic_score_gemma":0.001809481,"domain_scores_codex":[0.9998742,0.00002919968,0.00001011398,0.00001759357,0.00003305726,0.00003575188],"domain_scores_gemma":[0.9999232,0.00001297921,0.00001637784,0.00000871935,0.00001181859,0.00002697163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004762316,0.004465554,0.001058074,0.0004030477,0.0001344116,0.0003125897,0.00007868983,0.002007877,0.9450385,0.0003403197,0.001385265,0.04001321],"study_design_scores_gemma":[0.004043499,0.1383675,0.01369318,0.00008761975,0.0003281258,0.001316448,0.00009044422,0.003817389,0.8175633,0.0002839876,0.02037873,0.00002982699],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9777526,0.01226594,0.002934581,0.0005367378,0.0002003575,0.0007222994,0.001440564,0.0003198179,0.003827145],"genre_scores_gemma":[0.9887639,0.005667049,0.001394241,0.0001805053,0.00003980959,0.0002008708,0.001304137,0.00002041706,0.002428982],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001888557,"threshold_uncertainty_score":0.006317794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07668441025883248,"score_gpt":0.3614075094630266,"score_spread":0.2847230992041941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}