{"id":"W2903139826","doi":"10.1016/j.fertnstert.2018.10.012","title":"Vilaprisan in women with uterine fibroids: the randomized phase 2b ASTEROID 1 study","year":2018,"lang":"en","type":"article","venue":"Fertility and Sterility","topic":"Uterine Myomas and Treatments","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Bausch and Lomb Ireland; Allergan; Shionogi; Mount Sylvia Diatomite; Novo Nordisk; Bayer Fund; Covis Pharma; Radius Health; New England Research Institutes; Patient-Centered Outcomes Research Institute; Bayer HealthCare; Sanofi; Meso Scale Diagnostics; AbbVie; Merck; Gedeon Richter; Ferring; Bayer; Amgen","keywords":"Medicine; Uterine fibroids; Placebo; Amenorrhea; Randomized controlled trial; Gynecology; Menstruation; Clinical endpoint; Surgery; Internal medicine; Pregnancy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00089476,0.0002192207,0.0006902083,0.00004363455,0.0001189051,0.00004481229,0.00008598078,0.00004346012,0.0003206619],"category_scores_gemma":[0.00006011461,0.0001134087,0.00004542821,0.0001453244,0.0004588618,0.0001069306,0.0001227045,0.0001325143,0.00001008172],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006517748,"about_ca_system_score_gemma":0.00003403199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002547428,"about_ca_topic_score_gemma":0.0003885017,"domain_scores_codex":[0.9983603,0.0003208037,0.0003877874,0.0004226767,0.0001998957,0.0003085083],"domain_scores_gemma":[0.9990228,0.00008863457,0.00006502253,0.000616423,0.00006259335,0.0001445362],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.9287942,0.00249136,0.04836779,0.00007564398,0.0002109067,0.00005776174,0.006275781,3.860089e-8,0.0002453669,6.429841e-7,0.000008546703,0.01347194],"study_design_scores_gemma":[0.1605977,0.004027723,0.8331773,0.0000307744,0.00006063436,0.00001547976,0.0007381011,0.0001429809,0.0001529746,0.00007256268,0.0008902497,0.00009355754],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967452,0.00007514851,0.00007111551,0.0005349125,0.0000619162,0.001821788,0.00002091584,0.00004000006,0.00062895],"genre_scores_gemma":[0.999091,0.000006487266,0.00009162244,0.0002422072,0.00004567601,0.0002142645,0.000006517459,0.00001105616,0.0002911838],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7848095,"threshold_uncertainty_score":0.4624673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01953229020395535,"score_gpt":0.3121588149912903,"score_spread":0.2926265247873349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}