{"id":"W2903139826","doi":"10.1016/j.fertnstert.2018.10.012","title":"Vilaprisan in women with uterine fibroids: the randomized phase 2b ASTEROID 1 study","year":2018,"lang":"en","type":"article","venue":"Fertility and Sterility","topic":"Uterine Myomas and Treatments","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Bausch and Lomb Ireland; Allergan; Shionogi; Mount Sylvia Diatomite; Novo Nordisk; Bayer Fund; Covis Pharma; Radius Health; New England Research Institutes; Patient-Centered Outcomes Research Institute; Bayer HealthCare; Sanofi; Meso Scale Diagnostics; AbbVie; Merck; Gedeon Richter; Ferring; Bayer; Amgen","keywords":"Medicine; Uterine fibroids; Placebo; Amenorrhea; Randomized controlled trial; Gynecology; Menstruation; Clinical endpoint; Surgery; Internal medicine; Pregnancy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001774405,0.001035706,0.002010266,0.0003322151,0.0002695457,0.0005754218,0.0006670941,0.001339697,0.007626625],"category_scores_gemma":[0.001573839,0.0004501291,0.001184588,0.0002693672,0.000594274,0.0006622851,0.0003487161,0.001325368,0.0009264956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004260835,"about_ca_system_score_gemma":0.00097419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000401799,"about_ca_topic_score_gemma":0.0009990856,"domain_scores_codex":[0.9994404,0.0003740686,0.00002812868,0.00006542959,0.00003660072,0.00005544841],"domain_scores_gemma":[0.9993811,0.000185675,0.0002243182,0.00004170006,0.00003155561,0.0001356424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9736261,0.004505461,0.0006824821,0.0009298319,0.000404089,0.00003901479,0.00003711799,0.0002042288,0.0027963,0.00008910328,0.0006781727,0.01600811],"study_design_scores_gemma":[0.9612667,0.03649599,0.001101442,0.00003929889,0.0001835508,0.00002619087,0.00001141476,0.0001163255,0.0002225665,0.00005277241,0.0004779741,0.000005793669],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9742697,0.01153301,0.0009683037,0.001193612,0.0004695804,0.007452664,0.001928559,0.0001570006,0.002027779],"genre_scores_gemma":[0.9700308,0.007781313,0.00348631,0.001800474,0.000539177,0.01084545,0.001896727,0.00002969844,0.003590106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007626625,"threshold_uncertainty_score":0.02551359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01953229020395535,"score_gpt":0.3121588149912903,"score_spread":0.2926265247873349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}