{"id":"W2903197719","doi":"10.1101/480822","title":"Metabolism-Induced Oxidative Stress and DNA Damage Selectively Trigger Genome Instability in Polyploid Cells","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"National Institutes of Health","keywords":"Genome instability; DNA damage; Biology; Oxidative stress; Ploidy; Polyploid; Carcinogenesis; Reactive oxygen species; Chromosome instability; Cell biology; Genome; DNA repair; Candida albicans; Genetics; DNA; Gene; Chromosome; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001271243,0.0001871675,0.0002185396,0.0002876746,0.0001653665,0.0004035835,0.0001841307,0.0003317654,0.002070753],"category_scores_gemma":[0.0001305817,0.0001059306,0.0001687222,0.0001920363,0.000175488,0.0002155964,0.0003755378,0.0004416794,0.0003438596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003086872,"about_ca_system_score_gemma":0.0001352569,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005327658,"about_ca_topic_score_gemma":0.0004193991,"domain_scores_codex":[0.999892,0.00001224705,0.00001012465,0.00003097632,0.00003376085,0.0000209326],"domain_scores_gemma":[0.9998672,0.00002075847,0.00004121841,0.00002269939,0.00001514249,0.00003295791],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004968589,0.000006139102,0.0002187645,0.000009524628,0.000002187403,0.00004635512,0.000007452162,0.00002520993,0.9990702,0.00005222304,0.00002539361,0.0004868322],"study_design_scores_gemma":[0.000008169735,0.0001004128,0.0102503,0.000004612596,0.000007275765,0.0003892825,0.00004204604,0.000767415,0.986689,0.0002023867,0.001533012,0.000006019621],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932336,0.0008956419,0.003400903,0.0001583256,0.00003548762,0.0000214769,0.0006780356,0.00009060724,0.001485889],"genre_scores_gemma":[0.9960766,0.0002600693,0.001078522,0.00006917389,0.000006575854,0.00001420926,0.0005511994,0.00002053441,0.001923184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002070753,"threshold_uncertainty_score":0.006927371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01439374485662194,"score_gpt":0.2402495366675579,"score_spread":0.225855791810936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}