{"id":"W2903244880","doi":"10.1371/journal.pone.0208142","title":"Central adjudication of serious adverse events did not affect trial’s safety results: Data from the Efficacy of Nitric Oxide in Stroke (ENOS) trial","year":2018,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Meta-analysis and systematic reviews","field":"Decision Sciences","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Research Trainees Coordinating Centre; Medical Research Council; Stroke Association; University of Glasgow; Bupa Foundation; National Institute for Health and Care Research; London School of Hygiene and Tropical Medicine","keywords":"Adjudication; Medicine; Clinical trial; Adverse effect; Stroke (engine); Randomized controlled trial; Waiver; Internal medicine; Law","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.2493079,0.001134482,0.004592388,0.001087203,0.001426028,0.003825561,0.001494218,0.003191318,0.00700161],"category_scores_gemma":[0.4053958,0.0009023761,0.009981681,0.001828028,0.003537826,0.003252558,0.002339723,0.005728565,0.001274426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001502854,"about_ca_system_score_gemma":0.003522668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006888985,"about_ca_topic_score_gemma":0.001547397,"domain_scores_codex":[0.5976369,0.3275163,0.04252752,0.008867839,0.02134928,0.002102132],"domain_scores_gemma":[0.2773963,0.5332267,0.1039778,0.05205876,0.03030137,0.003039155],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.7108338,0.00163817,0.04186864,0.03126121,0.06651267,0.0003646154,0.003086532,0.002408821,0.001927981,0.003585732,0.02152692,0.1149849],"study_design_scores_gemma":[0.4866356,0.06636121,0.2264242,0.01724504,0.08570817,0.001648737,0.0009777962,0.009445676,0.009547799,0.01884667,0.07627147,0.0008875575],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.737657,0.08625499,0.06432301,0.01371315,0.006197602,0.02665038,0.01720333,0.0009639967,0.04703654],"genre_scores_gemma":[0.9706361,0.003101071,0.009912163,0.003861759,0.0008963437,0.007007299,0.002737078,0.0003143847,0.001533686],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7506921,"threshold_uncertainty_score":0.925737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.6627020326517151,"score_gpt":0.4620347254115894,"score_spread":0.2006673072401257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}