{"id":"W2903244975","doi":"10.5414/np301105","title":"ATRX protein loss and deregulation of PI3K/AKT pathway is frequent in pilocytic astrocytoma with anaplastic features","year":2018,"lang":"en","type":"article","venue":"Clinical Neuropathology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"ATRX; PTEN; Biology; Cancer research; PI3K/AKT/mTOR pathway; Pilocytic astrocytoma; Anaplastic astrocytoma; Immunohistochemistry; Glioma; Pathology; Astrocytoma; Medicine; Mutation; Genetics; Signal transduction; Gene; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002232667,0.0001629634,0.000490409,0.0001173077,0.00003233082,0.000006794647,0.00005599298,0.0001322332,0.00004124968],"category_scores_gemma":[0.0003959421,0.0001143716,0.00006119726,0.0001681323,0.0006154213,0.00003298095,0.00005165971,0.0002086257,0.00001884382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002158786,"about_ca_system_score_gemma":0.0000721165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001381605,"about_ca_topic_score_gemma":0.00008795477,"domain_scores_codex":[0.998473,0.0002198812,0.0004935906,0.000444745,0.0001400572,0.0002287152],"domain_scores_gemma":[0.9990098,0.0002764397,0.000164478,0.0003092882,0.0001096192,0.000130402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003536611,0.00150633,0.9592521,0.0001120566,0.0000516775,0.003918102,0.0001715204,0.000004019269,0.01349745,0.0005053797,0.0001288848,0.01731588],"study_design_scores_gemma":[0.004839651,0.01681424,0.9579355,0.000173961,0.00008083632,0.0007843929,0.00001195233,0.00008479723,0.01882243,0.0002196185,0.000137575,0.00009508997],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979284,0.0001288915,0.00006296329,0.001059236,0.00009238831,0.0005274299,0.000008848328,0.00002185172,0.0001699277],"genre_scores_gemma":[0.9978814,0.00001965206,0.00131606,0.0005605424,0.0001258136,0.00003233861,0.000006719643,0.00002082535,0.00003662015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01722079,"threshold_uncertainty_score":0.4663939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02538442188651946,"score_gpt":0.3187369380315456,"score_spread":0.2933525161450261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}