{"id":"W2903244975","doi":"10.5414/np301105","title":"ATRX protein loss and deregulation of PI3K/AKT pathway is frequent in pilocytic astrocytoma with anaplastic features","year":2018,"lang":"en","type":"article","venue":"Clinical Neuropathology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"ATRX; PTEN; Biology; Cancer research; PI3K/AKT/mTOR pathway; Pilocytic astrocytoma; Anaplastic astrocytoma; Immunohistochemistry; Glioma; Pathology; Astrocytoma; Medicine; Mutation; Genetics; Signal transduction; Gene; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001223064,0.0002858502,0.0001419094,0.0007332189,0.0002096517,0.0003248983,0.0002140379,0.0004068061,0.002152168],"category_scores_gemma":[0.0004532583,0.0001401555,0.0001506124,0.0004515268,0.0003558061,0.0002547668,0.0002504897,0.0001842775,0.000549047],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001746048,"about_ca_system_score_gemma":0.0001472149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003137336,"about_ca_topic_score_gemma":0.0004163572,"domain_scores_codex":[0.9998661,0.00001497764,0.00001671329,0.00002736089,0.00004188918,0.00003299152],"domain_scores_gemma":[0.9997805,0.00002936653,0.0001175471,0.00001946196,0.0000206967,0.0000325034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001023372,0.0001014286,0.4595746,0.0003045598,0.0001880389,0.1672745,0.0002994188,0.0004767951,0.3251823,0.0005810805,0.0009889023,0.04400492],"study_design_scores_gemma":[0.00002875561,0.0002221579,0.4584977,0.00002825725,0.0001512787,0.4930246,0.0002427407,0.0008351149,0.0437224,0.0005623677,0.002671968,0.00001268757],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961178,0.0007932462,0.0009660893,0.00006360414,0.000007725195,0.00001101742,0.000088396,0.0000650602,0.001887096],"genre_scores_gemma":[0.9993964,0.0001340155,0.0002033694,0.00001315711,0.000005708511,0.000003071726,0.00005333911,0.000003812551,0.0001870711],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002152168,"threshold_uncertainty_score":0.007199764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02538442188651946,"score_gpt":0.3187369380315456,"score_spread":0.2933525161450261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}