{"id":"W2903245161","doi":"10.1182/blood-2018-163","title":"The Believe Trial: Results of a Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Luspatercept in Adult Beta-Thalassemia Patients Who Require Regular Red Blood Cell (RBC) Transfusions","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Medicine; Thalassemia; Ineffective erythropoiesis; Beta thalassemia; Erythropoiesis; Placebo; Clinical endpoint; Internal medicine; Randomization; Anemia; Blood transfusion; Randomized controlled trial; Surgery; Gastroenterology; Pediatrics; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002152723,0.001755416,0.003034237,0.0003352143,0.0005385371,0.001357979,0.0009232537,0.002282797,0.01093159],"category_scores_gemma":[0.002315309,0.000608382,0.002083044,0.0003651334,0.001031267,0.001405994,0.000322705,0.003581548,0.001558046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005290161,"about_ca_system_score_gemma":0.0009223028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004710484,"about_ca_topic_score_gemma":0.001329652,"domain_scores_codex":[0.9994308,0.0002809704,0.00004525706,0.000114413,0.00005831796,0.00007020254],"domain_scores_gemma":[0.9989797,0.0003354545,0.0002727991,0.0000798814,0.0000962001,0.0002358212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9741501,0.005426798,0.0004245488,0.001283584,0.001360296,0.00006571493,0.0000671614,0.0002181893,0.003489532,0.0001813947,0.002389633,0.01094307],"study_design_scores_gemma":[0.9726307,0.02501567,0.0007645638,0.00003771411,0.0004195235,0.0000336709,0.00001587367,0.0002000441,0.0001966329,0.0001054968,0.0005689358,0.00001114221],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9471454,0.01609624,0.002493715,0.003225174,0.001799276,0.01401391,0.005603922,0.0006257737,0.008996528],"genre_scores_gemma":[0.9591986,0.006685628,0.003792522,0.004574012,0.001086139,0.01262469,0.003913996,0.0001014624,0.008022884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01093159,"threshold_uncertainty_score":0.03656977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01393108113748275,"score_gpt":0.2760082175400377,"score_spread":0.2620771364025549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}