{"id":"W2903245161","doi":"10.1182/blood-2018-163","title":"The Believe Trial: Results of a Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Luspatercept in Adult Beta-Thalassemia Patients Who Require Regular Red Blood Cell (RBC) Transfusions","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Medicine; Thalassemia; Ineffective erythropoiesis; Beta thalassemia; Erythropoiesis; Placebo; Clinical endpoint; Internal medicine; Randomization; Anemia; Blood transfusion; Randomized controlled trial; Surgery; Gastroenterology; Pediatrics; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002030254,0.0004001062,0.002066791,0.0002965485,0.0002076853,0.00001991556,0.0003210422,0.0003883886,0.00003389018],"category_scores_gemma":[0.0007491057,0.0002418719,0.0005326159,0.00065061,0.0004063505,0.00009610956,0.0000690403,0.0004428757,0.00000523188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002312362,"about_ca_system_score_gemma":0.000193522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005663967,"about_ca_topic_score_gemma":0.0005134769,"domain_scores_codex":[0.9949759,0.0007779857,0.002368939,0.0005705869,0.0007959933,0.0005105886],"domain_scores_gemma":[0.9967436,0.0005902729,0.0008200641,0.0009561523,0.0006998737,0.0001900765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9584843,0.02742293,0.0004061321,0.00009253901,0.001236501,0.00003078342,0.008592695,0.000005269763,0.00306403,0.00001591429,0.0002218064,0.0004270991],"study_design_scores_gemma":[0.967428,0.01092824,0.00007405857,0.0004177927,0.004232784,0.000005116824,0.003179645,0.0000993815,0.01331178,0.00002390371,0.00007865637,0.0002206015],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808657,0.0003516789,0.000005317627,0.0005232189,0.0002764377,0.01382715,0.00004657806,0.00004021097,0.004063778],"genre_scores_gemma":[0.9975431,0.0007457847,0.00005285464,0.00004136561,0.0001129113,0.0005012744,0.00004240838,0.00005542224,0.0009048685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01667748,"threshold_uncertainty_score":0.9863249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01393108113748275,"score_gpt":0.2760082175400377,"score_spread":0.2620771364025549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}