{"id":"W2903278833","doi":"10.1200/jco.18.01583","title":"Double-Hit Gene Expression Signature Defines a Distinct Subgroup of Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma","year":2018,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":420,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Princess Margaret Cancer Centre; Simon Fraser University; University Health Network; Spinal Cord Injury BC","funders":"National Cancer Institute; Medical Research Council; Canadian Institutes of Health Research; Canada's Michael Smith Genome Sciences Centre","keywords":"BCL6; Germinal center; Diffuse large B-cell lymphoma; Lymphoma; Medicine; Biology; Oncology; Cancer research; B cell; Genetics; Internal medicine; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001307663,0.0002796323,0.001792674,0.0001472253,0.00008160604,0.00001241179,0.0002604372,0.0006519896,0.0002707829],"category_scores_gemma":[0.00036694,0.0001726282,0.0008917786,0.0001501129,0.0002945603,0.0001109093,0.0001526576,0.0004001772,0.00005511391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002037051,"about_ca_system_score_gemma":0.0009003233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002372421,"about_ca_topic_score_gemma":0.00003468333,"domain_scores_codex":[0.9959488,0.0002986203,0.002437702,0.0003306922,0.000562667,0.0004215251],"domain_scores_gemma":[0.9948759,0.001211516,0.002310542,0.00037486,0.0006678161,0.0005593771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03285717,0.1613845,0.7094181,0.0001979495,0.0005666366,0.004402655,0.0004250132,4.586535e-7,0.01093971,0.00009715577,0.04281873,0.036892],"study_design_scores_gemma":[0.270009,0.03239545,0.4463611,0.0005074883,0.001486962,0.001397992,0.0001292222,0.0000534931,0.04700868,0.0001502406,0.2001547,0.0003456954],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911204,0.001302673,0.0001110478,0.00119817,0.001798758,0.0002506952,0.00002779584,0.00001280837,0.004177676],"genre_scores_gemma":[0.9916321,0.0006034633,0.003452854,0.001509881,0.002179553,0.000008573307,0.00001755906,0.00003122744,0.0005647776],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2630569,"threshold_uncertainty_score":0.7039574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05704772709452764,"score_gpt":0.392159535548267,"score_spread":0.3351118084537393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}