{"id":"W2903278833","doi":"10.1200/jco.18.01583","title":"Double-Hit Gene Expression Signature Defines a Distinct Subgroup of Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma","year":2018,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":420,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Princess Margaret Cancer Centre; Simon Fraser University; University Health Network; Spinal Cord Injury BC","funders":"National Cancer Institute; Medical Research Council; Canadian Institutes of Health Research; Canada's Michael Smith Genome Sciences Centre","keywords":"BCL6; Germinal center; Diffuse large B-cell lymphoma; Lymphoma; Medicine; Biology; Oncology; Cancer research; B cell; Genetics; Internal medicine; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001078925,0.0002261302,0.0002341711,0.0006067002,0.0001268725,0.0003095348,0.0001391253,0.000173658,0.0005597336],"category_scores_gemma":[0.0002579309,0.00007889955,0.0001405643,0.0004191222,0.0002529026,0.0001060681,0.0001811991,0.0001469516,0.0001461183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002143485,"about_ca_system_score_gemma":0.0001126653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003520868,"about_ca_topic_score_gemma":0.001001378,"domain_scores_codex":[0.9998857,0.00001427676,0.00001079785,0.00003503741,0.00002903377,0.00002501571],"domain_scores_gemma":[0.9997919,0.00003761883,0.00008150806,0.00002109944,0.00001934703,0.00004858383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007867625,0.00006442876,0.5560447,0.00006876011,0.00009576797,0.0009502084,0.0001187113,0.0003405991,0.4306338,0.00008011877,0.0001228382,0.01069324],"study_design_scores_gemma":[0.00004231397,0.0003982864,0.9612189,0.000006829793,0.00008129162,0.005655995,0.0001722441,0.001806592,0.02950397,0.0001298158,0.0009763488,0.000007530125],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994738,0.00008333928,0.0001687246,0.000006694114,6.534161e-7,0.000004292621,0.0001145272,0.000005934391,0.0001422603],"genre_scores_gemma":[0.9989626,0.00003542952,0.000291046,0.0000150857,0.00000263925,0.0000057211,0.0005960258,0.000003045389,0.000088332],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006067002,"threshold_uncertainty_score":0.00187254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05704772709452764,"score_gpt":0.392159535548267,"score_spread":0.3351118084537393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}