{"id":"W2903286690","doi":"10.1007/s12035-018-1427-8","title":"Kainate Receptor Activation Enhances Amyloidogenic Processing of APP in Astrocytes","year":2018,"lang":"en","type":"article","venue":"Molecular Neurobiology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Kainate receptor; Kainic acid; AMPA receptor; Glutamate receptor; Astrocyte; Amyloid precursor protein; Neuroscience; Receptor; Neurodegeneration; Chemistry; Alzheimer's disease; Biology; Cell biology; Pharmacology; Internal medicine; Biochemistry; Central nervous system; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006355398,0.0001015271,0.0001960788,0.0001324469,0.00002933343,0.000004204725,0.00006516639,0.00006193432,0.00006797256],"category_scores_gemma":[0.00007339579,0.00008475268,0.00004979765,0.0002219321,0.0001871734,0.0000427471,0.00003553387,0.00009375541,0.00004158705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000028386,"about_ca_system_score_gemma":0.000115829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001578528,"about_ca_topic_score_gemma":0.000003049832,"domain_scores_codex":[0.9991645,0.00008910404,0.0001671921,0.0002408887,0.00009153189,0.0002468213],"domain_scores_gemma":[0.9995824,0.00002152498,0.00007072549,0.0001456036,0.0001082308,0.00007154726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005530186,0.0002444773,0.006638473,0.00005001412,0.0002826235,0.0000244568,0.00005517066,0.000001291308,0.9866821,0.00002656933,0.00004254975,0.005399295],"study_design_scores_gemma":[0.0009881881,0.001020183,0.01480871,0.00006130813,0.0000405306,0.000007905291,0.00001907322,0.00003895426,0.9827029,0.00005564005,0.0001973374,0.00005929386],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983218,0.0004401399,0.0002024499,0.0001729779,0.00003036705,0.0002638487,0.000003919632,0.00002267555,0.0005418728],"genre_scores_gemma":[0.999252,0.00002451485,0.0004379347,0.0001464899,0.00003599794,0.00002525719,0.00004501332,0.00001390517,0.00001888493],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008170232,"threshold_uncertainty_score":0.3456114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01566144804031103,"score_gpt":0.3014068156094158,"score_spread":0.2857453675691048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}