{"id":"W2903286690","doi":"10.1007/s12035-018-1427-8","title":"Kainate Receptor Activation Enhances Amyloidogenic Processing of APP in Astrocytes","year":2018,"lang":"en","type":"article","venue":"Molecular Neurobiology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Kainate receptor; Kainic acid; AMPA receptor; Glutamate receptor; Astrocyte; Amyloid precursor protein; Neuroscience; Receptor; Neurodegeneration; Chemistry; Alzheimer's disease; Biology; Cell biology; Pharmacology; Internal medicine; Biochemistry; Central nervous system; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002252389,0.0003596519,0.0003934852,0.000224723,0.0003525557,0.0006255845,0.0002528773,0.0004332123,0.00234308],"category_scores_gemma":[0.0003036353,0.0002113942,0.0004691471,0.0002180988,0.0003074788,0.0005089755,0.0002672452,0.0009667115,0.00079345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002993017,"about_ca_system_score_gemma":0.0004181907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0012206,"about_ca_topic_score_gemma":0.001832151,"domain_scores_codex":[0.9996462,0.00006747019,0.00003244586,0.00003650941,0.00006372524,0.0001536791],"domain_scores_gemma":[0.9998504,0.00003211181,0.00001968525,0.00002857778,0.00002763587,0.00004162847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001381286,0.000113758,0.0001127964,0.00004950453,0.00001249749,0.0001608923,0.00005943139,0.00005084973,0.9967999,0.0001733637,0.00008691838,0.0009988075],"study_design_scores_gemma":[0.0001258313,0.001143934,0.006826508,0.00001379463,0.00005543812,0.0006012368,0.0002847567,0.0005899801,0.9884537,0.0002695369,0.001624124,0.00001122142],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957097,0.0008601883,0.0008537296,0.0001445329,0.00007236924,0.00001550544,0.0001368103,0.00003389447,0.002173277],"genre_scores_gemma":[0.9961234,0.0005642155,0.000512806,0.00006087901,0.00002676352,0.00002057393,0.0001691279,0.00001442215,0.002507822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00234308,"threshold_uncertainty_score":0.007838428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01566144804031103,"score_gpt":0.3014068156094158,"score_spread":0.2857453675691048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}