{"id":"W2903358057","doi":"10.1084/jem.20180668","title":"Loss of human ICOSL results in combined immunodeficiency","year":2018,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute; McGill University Health Centre","funders":"Astellas Pharma; Canadian Institutes of Health Research; McGill University Health Centre; Cidara Therapeutics; McGill University; Fonds de Recherche du Québec - Santé; Fondation du Grand défi Pierre Lavoie; CSL Behring; Bristol-Myers Squibb","keywords":"Biology; Immunodeficiency; Hypogammaglobulinemia; Mutation; Endoplasmic reticulum; Immunology; Primary immunodeficiency; Common variable immunodeficiency; Severe combined immunodeficiency; Antibody; Immunity; Gene; Cell biology; Immune system; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001045126,0.0004923478,0.0001824478,0.0004179131,0.0001615632,0.0002466565,0.0001762929,0.0003513842,0.001156231],"category_scores_gemma":[0.0001658538,0.00008675821,0.0001692625,0.0002321072,0.0003999391,0.0001197246,0.0002334413,0.0002906748,0.0003537943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002703557,"about_ca_system_score_gemma":0.0001614876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003867174,"about_ca_topic_score_gemma":0.0005023537,"domain_scores_codex":[0.9998579,0.00002993529,0.00002158633,0.00003178546,0.00003531979,0.00002351428],"domain_scores_gemma":[0.9999021,0.00002748142,0.0000230578,0.00001258538,0.000005091765,0.00002964009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003383319,0.00005007343,0.003433899,0.00005915174,0.00002020092,0.004382289,0.00004632484,0.0001626067,0.9866964,0.0003604653,0.0002002066,0.004250042],"study_design_scores_gemma":[0.00009894262,0.000918071,0.05690711,0.00004471661,0.0001279528,0.06871423,0.0001272232,0.002174768,0.8503278,0.0004754331,0.02006118,0.00002248297],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944447,0.001226233,0.001627179,0.00008150526,0.00002142444,0.00002772381,0.000708644,0.00009748848,0.001765027],"genre_scores_gemma":[0.9974629,0.0004916578,0.0007991886,0.00003376972,0.000007462721,0.00001427695,0.0006598018,0.00001320954,0.0005176836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001156231,"threshold_uncertainty_score":0.003867984,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01701783905612562,"score_gpt":0.2976675111223251,"score_spread":0.2806496720661995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}