{"id":"W2903358057","doi":"10.1084/jem.20180668","title":"Loss of human ICOSL results in combined immunodeficiency","year":2018,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute; McGill University Health Centre","funders":"Astellas Pharma; Canadian Institutes of Health Research; McGill University Health Centre; Cidara Therapeutics; McGill University; Fonds de Recherche du Québec - Santé; Fondation du Grand défi Pierre Lavoie; CSL Behring; Bristol-Myers Squibb","keywords":"Biology; Immunodeficiency; Hypogammaglobulinemia; Mutation; Endoplasmic reticulum; Immunology; Primary immunodeficiency; Common variable immunodeficiency; Severe combined immunodeficiency; Antibody; Immunity; Gene; Cell biology; Immune system; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001452093,0.0001502723,0.0004307127,0.0001981694,0.0001817928,0.000002234792,0.0005876225,0.00008663397,0.0004239276],"category_scores_gemma":[0.0001268199,0.00008783553,0.00007462884,0.0002762418,0.001797046,0.00008949183,0.00008097953,0.0003368075,0.00002767844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004187517,"about_ca_system_score_gemma":0.00004144583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003139002,"about_ca_topic_score_gemma":0.000002777671,"domain_scores_codex":[0.9982319,0.0002644281,0.001040666,0.0000969374,0.0001060371,0.0002599556],"domain_scores_gemma":[0.9988054,0.0001512037,0.0006270093,0.0003024456,0.0001071804,0.000006761012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001708145,0.0004864152,0.0001527369,0.000004214062,0.00004630673,0.000004544765,0.01544471,0.000001837416,0.9804434,0.0009056788,0.0003023873,0.0004996389],"study_design_scores_gemma":[0.01113929,0.008209236,0.009792318,0.0003985563,0.00004476884,0.0002489377,0.01838322,0.000003038698,0.9495873,0.0003552297,0.001699542,0.0001385707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9433656,0.05003555,0.00001133878,0.0006619548,0.000961065,0.0001172383,0.000002482524,0.000006231779,0.004838476],"genre_scores_gemma":[0.9994,0.0001290667,0.00000362037,0.0001200714,0.00001857118,0.000001155962,0.000006550004,0.000009628377,0.0003113606],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05603432,"threshold_uncertainty_score":0.6621292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01701783905612562,"score_gpt":0.2976675111223251,"score_spread":0.2806496720661995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}