{"id":"W2903396202","doi":"10.1021/acs.jmedchem.8b01809","title":"The Chimera That Curbs Appetite","year":2018,"lang":"en","type":"letter","venue":"Journal of Medicinal Chemistry","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"","keywords":"Chemistry; Chimera (genetics); Appetite; Neuroscience; Endocrinology; Biochemistry; Psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005213875,0.000306755,0.0004150475,0.0001440746,0.000510275,0.0007395321,0.0003659851,0.004738626,0.004340987],"category_scores_gemma":[0.001795503,0.0001704339,0.0005067902,0.0001060324,0.0009173856,0.0006719358,0.000449538,0.005408285,0.002186399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009896788,"about_ca_system_score_gemma":0.0005512688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005462781,"about_ca_topic_score_gemma":0.0007472627,"domain_scores_codex":[0.9997078,0.00007306627,0.0000209158,0.00005387877,0.00008608275,0.00005826417],"domain_scores_gemma":[0.9997,0.0001386215,0.00003324145,0.00003387627,0.00004998463,0.00004444207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001605076,0.0003395987,0.001899277,0.0005406525,0.0001646393,0.0231956,0.0004325708,0.0007199273,0.1029524,0.06215496,0.6397744,0.1662209],"study_design_scores_gemma":[0.0003851994,0.0004501883,0.0009444765,0.00008745319,0.00008592076,0.01538977,0.0001498605,0.001426479,0.02587128,0.007909585,0.9472572,0.000042538],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0581911,0.02678872,0.01111274,0.8149565,0.03080524,0.0001504439,0.0004797275,0.001051083,0.05646456],"genre_scores_gemma":[0.4563262,0.02325607,0.01264091,0.3727342,0.01233946,0.0003335013,0.0005706819,0.0002622299,0.1215367],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.004738626,"threshold_uncertainty_score":0.01452202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02733591998575242,"score_gpt":0.2633923342432603,"score_spread":0.2360564142575078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}