{"id":"W2903404198","doi":"10.1128/mbio.02321-18","title":"Potent Cas9 Inhibition in Bacterial and Human Cells by AcrIIC4 and AcrIIC5 Anti-CRISPR Proteins","year":2018,"lang":"en","type":"article","venue":"mBio","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; National Institute of General Medical Sciences; Government of Canada","keywords":"CRISPR; Cas9; Computational biology; Biology; Genome editing; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003597538,0.0003316541,0.0003260772,0.000221981,0.0001668786,0.0005161751,0.0002775185,0.0003625676,0.003175697],"category_scores_gemma":[0.000285604,0.0001044019,0.0002406231,0.0002160547,0.0002343386,0.0001357801,0.0002140689,0.0005633099,0.0009467369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000451402,"about_ca_system_score_gemma":0.0004067169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002341414,"about_ca_topic_score_gemma":0.002314334,"domain_scores_codex":[0.9995945,0.00009349607,0.00004025153,0.00009247752,0.00012427,0.00005500819],"domain_scores_gemma":[0.9998915,0.00002843701,0.00002126465,0.00002088878,0.00001954956,0.00001834407],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002273588,0.0000497418,0.0003474733,0.00008191726,0.00001510968,0.0000839571,0.00002832373,0.0001936438,0.9909562,0.0005788608,0.0006175063,0.006819851],"study_design_scores_gemma":[0.00001861138,0.0001926557,0.001019006,0.000008238219,0.00001142222,0.0003023305,0.00001390683,0.0007779235,0.9881855,0.00005942599,0.009406249,0.000004722508],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9226727,0.0176173,0.02817883,0.0008644444,0.000232148,0.0001491277,0.002632471,0.0008262288,0.02682672],"genre_scores_gemma":[0.9786125,0.00292577,0.007370874,0.0002127442,0.00001429336,0.00006684066,0.001860449,0.00005563498,0.008880853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003175697,"threshold_uncertainty_score":0.01062381,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004524391426523972,"score_gpt":0.26025837679456,"score_spread":0.255733985368036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}