{"id":"W2903412904","doi":"10.1126/scisignal.aar5536","title":"FZD <sub>5</sub> is a Gα <sub>q</sub> -coupled receptor that exhibits the functional hallmarks of prototypical GPCRs","year":2018,"lang":"en","type":"article","venue":"Science Signaling","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; Institute for Research in Immunology and Cancer","funders":"Novo Nordisk Fonden; FP7 People: Marie-Curie Actions; Vetenskapsrådet; Canadian Institutes of Health Research; Stiftelsen Olle Engkvist Byggmästare; Novo Nordisk; Deutsche Forschungsgemeinschaft; Knut och Alice Wallenbergs Stiftelse; Svenska Sällskapet för Medicinsk Forskning; Cancerfonden","keywords":"Heterotrimeric G protein; G protein-coupled receptor; Receptor; Cell biology; G protein; Chemistry; Signal transduction; Ligand (biochemistry); Gq alpha subunit; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000145671,0.0004457839,0.0003152448,0.0003091935,0.0003630164,0.0006272239,0.0003062142,0.0004215492,0.003477834],"category_scores_gemma":[0.0001636235,0.0001312304,0.0003974601,0.0002989165,0.0006146705,0.0003916488,0.0003164882,0.0004321399,0.001973336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008611295,"about_ca_system_score_gemma":0.0003585418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002819729,"about_ca_topic_score_gemma":0.003096277,"domain_scores_codex":[0.9998909,0.00001096167,0.000007772759,0.00001970355,0.00004276156,0.00002786751],"domain_scores_gemma":[0.9999504,0.000005059347,0.0000198624,0.000004361076,0.000006301445,0.00001395245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003009154,0.0000239515,0.001591264,0.0001551156,0.00002411219,0.0005197575,0.00003655577,0.0003159509,0.964129,0.01121464,0.001879264,0.01980948],"study_design_scores_gemma":[0.00007959872,0.0006133402,0.02569486,0.00003623046,0.0001132526,0.006003925,0.0002740694,0.002495432,0.873861,0.004097989,0.08669056,0.00003978318],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9101081,0.02078415,0.03157656,0.002367717,0.0003547524,0.0001524416,0.003310173,0.001052163,0.03029409],"genre_scores_gemma":[0.9756936,0.005704621,0.008613898,0.000418689,0.0000551626,0.00003390295,0.00184843,0.00003724189,0.007594507],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003477834,"threshold_uncertainty_score":0.01163453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01780578531593706,"score_gpt":0.2378669951124076,"score_spread":0.2200612097964705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}