{"id":"W2903415377","doi":"10.1371/journal.ppat.1007473","title":"The afc antifungal activity cluster, which is under tight regulatory control of ShvR, is essential for transition from intracellular persistence of Burkholderia cenocepacia to acute pro-inflammatory infection","year":2018,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Fundação para a Ciência e a Tecnologia; Ministère de l'Education Nationale, de l'Enseignement Superieur et de la Recherche; Institut National de la Santé et de la Recherche Médicale; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Burkholderia cenocepacia; Biology; Microbiology; Virulence; Biofilm; Burkholderia cepacia complex; Galleria mellonella; Zebrafish; Burkholderia; Gene; Bacteria; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000151359,0.0004791675,0.0003187231,0.000332913,0.0003240371,0.0003297919,0.0002862083,0.0003835104,0.001272474],"category_scores_gemma":[0.0002338545,0.0001893213,0.0003890319,0.0002098711,0.000399125,0.0001538875,0.0005544585,0.000609965,0.0008016663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006173266,"about_ca_system_score_gemma":0.000507987,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003773335,"about_ca_topic_score_gemma":0.003544827,"domain_scores_codex":[0.9995989,0.00003921098,0.00003279232,0.0001256398,0.0001269653,0.00007659717],"domain_scores_gemma":[0.9997242,0.00004475351,0.0001028329,0.00002930378,0.00004026581,0.00005854575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006143242,0.000006875338,0.0002345511,0.00002192817,0.000001892636,0.00005982968,0.00001553363,0.00004816164,0.9983285,0.0001216585,0.00005693302,0.001042689],"study_design_scores_gemma":[0.00004768699,0.0001949499,0.05254085,0.00003996453,0.00001965669,0.0008087931,0.0001319833,0.00398514,0.9325094,0.0002263912,0.009460867,0.0000343898],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824069,0.002094257,0.01023296,0.0001847299,0.00007133574,0.00004995812,0.002040333,0.0006044907,0.002315059],"genre_scores_gemma":[0.9924328,0.000252094,0.003450244,0.00007877705,0.000008544936,0.00003380383,0.001423004,0.0000774137,0.002243328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003773335,"threshold_uncertainty_score":0.007502735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01914579406718971,"score_gpt":0.2780181348251641,"score_spread":0.2588723407579744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}