{"id":"W2903498078","doi":"10.1016/j.celrep.2018.10.098","title":"Talin Autoinhibition Regulates Cell-ECM Adhesion Dynamics and Wound Healing In Vivo","year":2018,"lang":"en","type":"article","venue":"Cell Reports","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of British Columbia","funders":"Biotechnology and Biological Sciences Research Council; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Human Frontier Science Program; Directorate for Biological Sciences; Canada Foundation for Innovation","keywords":"Integrin; Focal adhesion; Cell biology; Extracellular matrix; Cell adhesion; Chemistry; Cell migration; Adhesion; Wound healing; Cytoskeleton; Cell; Biology; Signal transduction; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001364473,0.000213773,0.0001679406,0.0003416256,0.0001833244,0.0004367534,0.0002170404,0.0002294864,0.0007503201],"category_scores_gemma":[0.0001663568,0.0001648477,0.0001293417,0.0001253682,0.0003531666,0.0002426947,0.0002153862,0.0004295805,0.0002725337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004565606,"about_ca_system_score_gemma":0.0002028624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004418007,"about_ca_topic_score_gemma":0.0005580936,"domain_scores_codex":[0.9998567,0.00001912643,0.00000966631,0.0000267012,0.00003524813,0.00005255144],"domain_scores_gemma":[0.9997867,0.00002057521,0.00009330347,0.00001522577,0.00001559242,0.00006854715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001034394,0.00002027747,0.0003493883,0.000008198746,0.000002294958,0.00003067953,0.000009743228,0.0000572779,0.9983359,0.0001157042,0.00002228742,0.0009449281],"study_design_scores_gemma":[0.00002349923,0.0001879667,0.03179035,0.00000599402,0.00002147598,0.0002472267,0.00004937683,0.003248305,0.9631019,0.0002491745,0.00106741,0.000007287556],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964759,0.001043176,0.001534737,0.00005625997,0.00001070969,0.000006271088,0.00004739124,0.0000574969,0.0007681116],"genre_scores_gemma":[0.9981823,0.0003443634,0.0003640938,0.00002787609,0.000005945625,0.00000850493,0.00005066401,0.00001505037,0.001001237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007503201,"threshold_uncertainty_score":0.003312588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01346684443152397,"score_gpt":0.2801509618497744,"score_spread":0.2666841174182505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}