{"id":"W2903498078","doi":"10.1016/j.celrep.2018.10.098","title":"Talin Autoinhibition Regulates Cell-ECM Adhesion Dynamics and Wound Healing In Vivo","year":2018,"lang":"en","type":"article","venue":"Cell Reports","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of British Columbia","funders":"Biotechnology and Biological Sciences Research Council; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Human Frontier Science Program; Directorate for Biological Sciences; Canada Foundation for Innovation","keywords":"Integrin; Focal adhesion; Cell biology; Extracellular matrix; Cell adhesion; Chemistry; Cell migration; Adhesion; Wound healing; Cytoskeleton; Cell; Biology; Signal transduction; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006302788,0.0001804744,0.0002930438,0.0002778246,0.0001094658,0.00004446451,0.00004342767,0.0001906071,0.0004138047],"category_scores_gemma":[0.0001436513,0.0001704969,0.00006302899,0.0003164,0.0001731846,0.00007933664,0.0001229627,0.0002707236,0.00003153008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002446914,"about_ca_system_score_gemma":0.0001599033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001567817,"about_ca_topic_score_gemma":0.00009994538,"domain_scores_codex":[0.9979675,0.000060417,0.0005588477,0.0005506368,0.0004686999,0.0003939134],"domain_scores_gemma":[0.9988505,0.00006755394,0.0001795368,0.0005049943,0.0001586951,0.0002387183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001531247,0.0002813736,0.0212662,0.0004243615,0.000006126162,0.00389977,0.0003285697,0.00001156565,0.9671371,0.00002154211,0.003937587,0.002532653],"study_design_scores_gemma":[0.0008783739,0.0004932598,0.009532451,0.0002992869,0.00002751935,0.0008809689,0.0002265692,0.01143437,0.972155,0.0006521536,0.003179039,0.000240948],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9765854,0.000413957,0.0001516506,0.0002830464,0.0001626531,0.000503873,0.000001782869,0.00006548829,0.02183214],"genre_scores_gemma":[0.9835129,0.0001288971,0.001167055,0.0001280977,0.0001428661,0.0000122288,0.00004631014,0.00004411748,0.01481749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01173375,"threshold_uncertainty_score":0.6952663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01346684443152397,"score_gpt":0.2801509618497744,"score_spread":0.2666841174182505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}