{"id":"W2903559354","doi":"10.1038/s41467-018-07481-7","title":"Force-dependent allostery of the α-catenin actin-binding domain controls adherens junction dynamics and functions","year":2018,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"Core Research for Evolutional Science and Technology; Division of Chemistry; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Princess Margaret Cancer Foundation; Northwestern University; Canada First Research Excellence Fund; Canadian Light Source; National Institutes of Health; National Science Foundation","keywords":"Adherens junction; Allosteric regulation; Actin; Actin cytoskeleton; Cell biology; Catenin; Actin remodeling; Cadherin; Actin-binding protein; Biology; MDia1; Plasma protein binding; Cytoskeleton; Biophysics; Chemistry; Biochemistry; Wnt signaling pathway; Signal transduction; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008918905,0.0001379694,0.0001146205,0.0001316417,0.0001853409,0.0002581826,0.0001720253,0.0001765257,0.0006893198],"category_scores_gemma":[0.0001420384,0.0001052964,0.0001236509,0.00008734402,0.0002045141,0.0001984538,0.0001681404,0.0002641006,0.0001860273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002951782,"about_ca_system_score_gemma":0.0001285627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006786091,"about_ca_topic_score_gemma":0.0007493579,"domain_scores_codex":[0.9999233,0.000008588722,0.000004520081,0.00001843378,0.00002396627,0.00002118308],"domain_scores_gemma":[0.9999379,0.000008413122,0.00001950583,0.000007321657,0.000007991773,0.00001883591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003580469,0.000007421022,0.0004917757,0.000007023356,0.000001695781,0.00002097555,0.000009703014,0.0001794775,0.9981362,0.0001728044,0.00001367007,0.0009235541],"study_design_scores_gemma":[0.00002239607,0.000144474,0.06094981,0.00001174686,0.00001581084,0.000306286,0.00008662839,0.01926453,0.9163808,0.00045514,0.002347992,0.00001439909],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978619,0.0003524146,0.0009921815,0.00002884905,0.000004355468,0.000005032623,0.00003043965,0.0000211139,0.0007036744],"genre_scores_gemma":[0.9992964,0.0001360014,0.0002149087,0.000007311129,0.000001541982,0.000002982872,0.00002642135,0.00000244838,0.0003118829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006893198,"threshold_uncertainty_score":0.002306044,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009847537943910765,"score_gpt":0.2597024744195234,"score_spread":0.2498549364756127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}