{"id":"W2903560348","doi":"10.20944/preprints201811.0609.v1","title":"Exploiting Autoimmunity Unleashed by an Off-Label Low-Dose Immune Checkpoint Blockade to Treat Advanced Cancer","year":2018,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Ipilimumab; Medicine; Immunotherapy; Adverse effect; Blockade; Cancer immunotherapy; Cancer; Nivolumab; Population; Immune checkpoint; Immunology; Autoimmunity; Immune system; Oncology; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000370492,0.0002738895,0.0003790512,0.000296,0.0001309707,0.0005469295,0.000278852,0.0002996929,0.002311577],"category_scores_gemma":[0.0002860405,0.00009384455,0.0004179054,0.0001708062,0.0002620669,0.0004656492,0.0003555894,0.001884297,0.0008756199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003016401,"about_ca_system_score_gemma":0.0002807035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002476852,"about_ca_topic_score_gemma":0.0006501113,"domain_scores_codex":[0.9998326,0.00003330063,0.000009102097,0.00002108392,0.00006704445,0.00003680504],"domain_scores_gemma":[0.9999243,0.00001406656,0.00001749109,0.000008687594,0.00001746642,0.00001787227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.002235912,0.001356896,0.001040081,0.002339339,0.0002316043,0.0004710861,0.0001412578,0.001348093,0.3355579,0.008604969,0.03300463,0.6136683],"study_design_scores_gemma":[0.001404572,0.01186975,0.006611827,0.0008174664,0.0006426701,0.004635093,0.0001764452,0.005840411,0.2420437,0.01160333,0.7142548,0.0000999664],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.3338022,0.5594871,0.04169129,0.0131214,0.006242639,0.0003586815,0.0005998042,0.001393584,0.04330328],"genre_scores_gemma":[0.7859768,0.1703799,0.008588125,0.00737541,0.001856962,0.000258969,0.0006486095,0.000132647,0.02478265],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002311577,"threshold_uncertainty_score":0.007733047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09678417388093633,"score_gpt":0.3788941730114344,"score_spread":0.2821099991304981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}