{"id":"W2903564686","doi":"10.1177/0883073818813238","title":"mTOR Inhibitors as a New Therapeutic Strategy in Treatment Resistant Epilepsy in Hemimegalencephaly: A Case Report","year":2018,"lang":"en","type":"article","venue":"Journal of Child Neurology","topic":"Tuberous Sclerosis Complex Research","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary; University of Toronto; BC Children's Hospital; Hospital for Sick Children; University of British Columbia","funders":"","keywords":"Hemimegalencephaly; Hemispherectomy; Megalencephaly; Cortical dysplasia; Tuberous sclerosis; PI3K/AKT/mTOR pathway; Medicine; Epileptogenesis; Sirolimus; Hippocampal sclerosis; Epilepsy; Ketogenic diet; Internal medicine; Pathology; Biology; Psychiatry; Temporal lobe","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005831635,0.0002004394,0.0006256234,0.0006472712,0.00005461903,0.00001971635,0.0001383193,0.0001535058,0.0003040475],"category_scores_gemma":[0.0003548419,0.0001515653,0.0001512983,0.0004421617,0.0001923194,0.0001000742,0.00004016105,0.0007462974,0.0000223795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000194097,"about_ca_system_score_gemma":0.000895176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008409839,"about_ca_topic_score_gemma":0.001455637,"domain_scores_codex":[0.9975653,0.000275309,0.001007849,0.0003186094,0.0003659616,0.0004669987],"domain_scores_gemma":[0.9985762,0.0001754147,0.0003628538,0.0003742511,0.0001370698,0.0003742637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.01307968,0.001864509,0.1259775,0.00003122009,0.0001778761,0.8087624,0.0009536247,0.0000566341,0.01852903,0.0001959384,0.005171624,0.0252],"study_design_scores_gemma":[0.0089996,0.02723518,0.2482566,0.0001870098,0.00008014489,0.6891341,0.00006884481,0.00009944243,0.006026193,0.00084208,0.01889033,0.0001804639],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9417945,0.0006493292,0.000003327797,0.05503737,0.0001967323,0.000328392,0.000001116132,0.00001010431,0.001979111],"genre_scores_gemma":[0.9941227,0.0001369946,0.00003473642,0.004566721,0.0008289899,0.000005490106,8.705491e-7,0.00002911313,0.0002743467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1222791,"threshold_uncertainty_score":0.6180652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04661578780026491,"score_gpt":0.3384489657294347,"score_spread":0.2918331779291697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}