{"id":"W2903610511","doi":"10.1016/j.ymthe.2018.12.003","title":"The Bumpy Road to CAR Activation","year":2018,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Chimeric antigen receptor; Immunotherapy; Scopus; CD28; T cell; Cancer immunotherapy; Cancer research; Biology; T-cell receptor; Cell biology; Immunology; Immune system; Biochemistry; MEDLINE","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004278828,0.0008151174,0.001300839,0.001225627,0.001275707,0.00461024,0.001644122,0.00544476,0.02826085],"category_scores_gemma":[0.007793074,0.0005774518,0.0009363617,0.0008710893,0.004047076,0.01097179,0.003604802,0.01561013,0.01298381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002036192,"about_ca_system_score_gemma":0.002343919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001246895,"about_ca_topic_score_gemma":0.001354277,"domain_scores_codex":[0.9980417,0.0005017982,0.00006832169,0.0003531869,0.0006284016,0.0004065527],"domain_scores_gemma":[0.9963457,0.001638458,0.0001214447,0.0002785665,0.0009010314,0.0007148487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005045081,0.0001697092,0.0005576015,0.001632459,0.00005704412,0.0004196095,0.0004705642,0.0007583205,0.007280745,0.2699492,0.3922594,0.3259408],"study_design_scores_gemma":[0.00003120311,0.0001619501,0.0001860044,0.0004209433,0.00001279388,0.0003170778,0.0002186824,0.0004384483,0.002896031,0.06775869,0.9275232,0.00003490902],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"other","genre_scores_codex":[0.006302574,0.5437046,0.02526326,0.3368687,0.02393591,0.00008835232,0.0008145592,0.001175521,0.06184657],"genre_scores_gemma":[0.1227521,0.5815763,0.02246695,0.1506955,0.02161682,0.0004584988,0.001568529,0.0008566016,0.09800866],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.02826085,"threshold_uncertainty_score":0.09454197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0272269844559087,"score_gpt":0.3419275600672362,"score_spread":0.3147005756113275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}