{"id":"W2903641700","doi":"10.1016/j.immuni.2018.11.011","title":"Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers","year":2018,"lang":"en","type":"article","venue":"Immunity","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":175,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal; Université du Québec à Montréal","funders":"Canadian Institutes of Health Research; National Institutes of Health; International AIDS Vaccine Initiative; Achievement Rewards for College Scientists Foundation; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation","keywords":"Virology; Titer; Antibody; Neutralizing antibody; Biology; Vaccination; Immunology; Antibody titer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002664555,0.0005853541,0.0003063362,0.0002972024,0.0001385995,0.0002496371,0.0001733268,0.0003748976,0.002243527],"category_scores_gemma":[0.0002842268,0.0001644775,0.0001945419,0.00009913694,0.0002186989,0.0002547848,0.0001658405,0.0008733452,0.0005406935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000277806,"about_ca_system_score_gemma":0.0002885963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001185454,"about_ca_topic_score_gemma":0.002054755,"domain_scores_codex":[0.9998437,0.00003105469,0.00001242664,0.00002909569,0.00003351772,0.00005027831],"domain_scores_gemma":[0.9998336,0.00003936081,0.00003091228,0.00002961817,0.00002551624,0.00004104185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004912115,0.0003542152,0.0006800883,0.00005944348,0.00001325022,0.00003277153,0.00005263804,0.0001602765,0.9936728,0.0001355689,0.0001209757,0.004226644],"study_design_scores_gemma":[0.0001150949,0.011559,0.0249654,0.00004232724,0.00004116161,0.0004638656,0.0000832307,0.001935023,0.9562965,0.0004764412,0.004002583,0.00001924214],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937928,0.0007555409,0.001937187,0.00008312607,0.00004572158,0.0001283161,0.0003581437,0.0001065803,0.002792517],"genre_scores_gemma":[0.9956297,0.0004563483,0.0009728923,0.0000651003,0.00001298196,0.00007651693,0.0004263106,0.00001491868,0.002345231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002243527,"threshold_uncertainty_score":0.007505298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03850142921018614,"score_gpt":0.3164064679754343,"score_spread":0.2779050387652481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}