{"id":"W2903679873","doi":"10.1128/aac.01804-18","title":"Evaluation of 4-Amino 2-Anilinoquinazolines against Plasmodium and Other Apicomplexan Parasites In Vitro and in a P. falciparum Humanized NOD- scid IL2Rγ null Mouse Model of Malaria","year":2018,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Malaria Research and Control","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; National Health and Medical Research Council; Australian Research Council; Australian Cancer Research Foundation; International Development Research Centre; Department of Education and Training; Howard Hughes Medical Institute","keywords":"Plasmodium falciparum; Nod; Virology; Apicomplexa; In vitro; Biology; Microbiology; Protozoal disease; Malaria; Protozoa; Immunology; In vivo; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001010464,0.0003019207,0.0007391032,0.0002432262,0.00007057295,0.000037336,0.0001292837,0.0001842568,0.00006475372],"category_scores_gemma":[0.00005472719,0.000263981,0.00007705024,0.0002026868,0.000408792,0.0001312593,0.000067539,0.000190961,0.000001605947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003736866,"about_ca_system_score_gemma":0.0001343184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002930501,"about_ca_topic_score_gemma":0.0001680739,"domain_scores_codex":[0.9978447,0.000154156,0.0006056911,0.0004966219,0.0004670288,0.0004318164],"domain_scores_gemma":[0.9990175,0.00005482833,0.0001868203,0.0002964817,0.0003046382,0.0001397817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003582302,0.0006599959,0.02937848,0.0002195483,0.0001396768,0.000003562552,0.001340196,0.00009095208,0.9568864,0.00008136973,0.0005938614,0.007023627],"study_design_scores_gemma":[0.04412498,0.0006488468,0.03062784,0.0003900324,0.000281257,0.00002710879,0.0002189536,0.2890639,0.6329321,0.0003337979,0.0007693556,0.0005818066],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966882,0.0001708455,0.00007413828,0.001319147,0.00001774506,0.00102887,0.0001215062,0.00001601959,0.000563517],"genre_scores_gemma":[0.993929,0.0006456092,0.0009497541,0.004127098,0.00008009012,0.00002414051,0.00002957169,0.00004506955,0.0001697049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3239543,"threshold_uncertainty_score":0.9999812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03870281394728005,"score_gpt":0.3035684451884704,"score_spread":0.2648656312411903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}