{"id":"W2903679873","doi":"10.1128/aac.01804-18","title":"Evaluation of 4-Amino 2-Anilinoquinazolines against Plasmodium and Other Apicomplexan Parasites In Vitro and in a P. falciparum Humanized NOD- scid IL2Rγ null Mouse Model of Malaria","year":2018,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Malaria Research and Control","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; National Health and Medical Research Council; Australian Research Council; Australian Cancer Research Foundation; International Development Research Centre; Department of Education and Training; Howard Hughes Medical Institute","keywords":"Plasmodium falciparum; Nod; Virology; Apicomplexa; In vitro; Biology; Microbiology; Protozoal disease; Malaria; Protozoa; Immunology; In vivo; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002033676,0.0004036501,0.0003239145,0.0002331534,0.0001130687,0.0001810738,0.000278649,0.000253445,0.0008849688],"category_scores_gemma":[0.0001701363,0.0001440454,0.0002331912,0.0001375373,0.0001383922,0.0001852056,0.00008508963,0.0002749436,0.0001321267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001568019,"about_ca_system_score_gemma":0.0001782569,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006419946,"about_ca_topic_score_gemma":0.002288369,"domain_scores_codex":[0.9999025,0.00003810222,0.000009384693,0.00001353107,0.00001893659,0.00001752096],"domain_scores_gemma":[0.9998605,0.0000268865,0.00004347652,0.000008477547,0.00003306415,0.00002759522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009445647,0.0002837476,0.0003994313,0.0002399128,0.00003184778,0.00009843806,0.00002605097,0.0007373242,0.9906784,0.00005349887,0.0001278618,0.006378902],"study_design_scores_gemma":[0.0005349334,0.02590644,0.007248791,0.00004266417,0.0001561609,0.0005317506,0.00004773201,0.001129833,0.9585609,0.00004131156,0.005776232,0.00002319761],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913196,0.005173865,0.000892139,0.00008778943,0.0000299319,0.0001491962,0.0003752145,0.00004272517,0.001929641],"genre_scores_gemma":[0.9889007,0.005704999,0.002622622,0.00009437712,0.00002113197,0.00008241089,0.0006234316,0.00001208476,0.001938363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008849688,"threshold_uncertainty_score":0.002960563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03870281394728005,"score_gpt":0.3035684451884704,"score_spread":0.2648656312411903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}