{"id":"W2903767004","doi":"10.1128/jvi.01502-18","title":"Genotypic and Mechanistic Characterization of Subtype-Specific HIV Adaptation to Host Cellular Immunity","year":2018,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; AIDS Vancouver; Simon Fraser University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Cancer Institute; Government of Canada; National Institutes of Health; Michael Smith Health Research BC; Canada Research Chairs","keywords":"Biology; Human leukocyte antigen; Epitope; Context (archaeology); Virology; Immune system; Major histocompatibility complex; Immunogenicity; Genetics; Population; Immunity; Genotype; Immunology; Genetic variation; Antigen; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003190484,0.0001098823,0.0001531998,0.0001361318,0.0001051622,0.0003813564,0.0002175731,0.0002037754,0.0008829979],"category_scores_gemma":[0.0004439212,0.00007155849,0.0001237136,0.0001770054,0.0001721039,0.0002452093,0.0001373173,0.0003551432,0.000140121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002404731,"about_ca_system_score_gemma":0.0001703602,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003942297,"about_ca_topic_score_gemma":0.0004705054,"domain_scores_codex":[0.9998554,0.00004391254,0.00001129598,0.00002640141,0.00003309711,0.0000297848],"domain_scores_gemma":[0.9998378,0.00004351988,0.00003587814,0.00005052502,0.00001703595,0.00001520756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002094476,0.00005017718,0.01391185,0.00004706864,0.0000142365,0.00007969826,0.00003491352,0.002485201,0.9712243,0.001428918,0.00005791275,0.01045636],"study_design_scores_gemma":[0.00003851868,0.00122954,0.2042562,0.00002866049,0.00008311548,0.002037394,0.000344488,0.03232047,0.7507843,0.003698366,0.005141207,0.00003777333],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956694,0.000312713,0.002680105,0.0000291339,0.000003180691,0.0000127018,0.0002487411,0.00001351256,0.001030458],"genre_scores_gemma":[0.9979955,0.0001574349,0.001401292,0.00002652884,0.000002465524,0.000009662902,0.0002009924,0.000005941412,0.0002002457],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008829979,"threshold_uncertainty_score":0.002953887,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01826490361328502,"score_gpt":0.2396352452800715,"score_spread":0.2213703416667865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}