{"id":"W2903769801","doi":"10.1182/blood-2018-99-113818","title":"Realizing Effectiveness across Continents with Hydroxyurea (REACH): A Prospective Multi-National Trial of Hydroxyurea for Sickle Cell Anemia in Sub-Saharan Africa","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital","funders":"","keywords":"Medicine; Anemia; Malaria; Clinical trial; Sickle cell anemia; Pediatrics; Prospective cohort study; Disease; Internal medicine; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003568321,0.00111167,0.00123171,0.0003184959,0.0006609471,0.0007621777,0.0005670856,0.0009282182,0.003154136],"category_scores_gemma":[0.002311916,0.0004518203,0.001299365,0.0003968618,0.001029322,0.001070836,0.0008399468,0.001847837,0.0003160712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006137391,"about_ca_system_score_gemma":0.001166772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009534509,"about_ca_topic_score_gemma":0.002577522,"domain_scores_codex":[0.9984145,0.001159643,0.00007088134,0.0001191043,0.00007440169,0.0001613708],"domain_scores_gemma":[0.9979067,0.0005070405,0.0006769001,0.0001515124,0.0001119631,0.0006459435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9001606,0.03668776,0.01657055,0.0006999096,0.002597803,0.0001790102,0.0005489367,0.001478075,0.00501323,0.0004000096,0.00122451,0.03443968],"study_design_scores_gemma":[0.6744505,0.2980523,0.02260113,0.00008252466,0.001173044,0.0001234708,0.000273778,0.0007213951,0.0009634792,0.0003617222,0.001167915,0.00002881585],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967777,0.0005344474,0.000184934,0.0002091984,0.00003101407,0.00131221,0.0003253644,0.0000196899,0.0006053564],"genre_scores_gemma":[0.9950585,0.0003994931,0.0008961608,0.0003120372,0.0000672481,0.002507738,0.0003159519,0.000005525227,0.0004373245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003568321,"threshold_uncertainty_score":0.01887131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01533450231967114,"score_gpt":0.280819502946299,"score_spread":0.2654850006266278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}