{"id":"W2903797156","doi":"10.3390/cancers10120524","title":"BRCA Mutations and Breast Cancer Prevention","year":2018,"lang":"en","type":"review","venue":"Cancers","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's College Hospital; University of Toronto","funders":"","keywords":"Breast cancer; Medicine; Mammography; BRCA mutation; Cancer; Oncology; Mastectomy; Prophylactic Mastectomy; Mutation; Gynecology; Internal medicine; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00008789703,0.0002629357,0.0003908824,0.00007353866,0.0001086014,0.0000346498,0.0001758708,0.0002918246,0.0001556051],"category_scores_gemma":[0.00001667184,0.0002516494,0.000179653,0.0001708836,0.0002086414,0.000004100645,0.00008544683,0.0001141087,0.00002104716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008742532,"about_ca_system_score_gemma":0.003269111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007244146,"about_ca_topic_score_gemma":0.0002350939,"domain_scores_codex":[0.998851,0.00004820781,0.000267842,0.0005277282,0.00009721996,0.0002079888],"domain_scores_gemma":[0.9992352,0.000009671084,0.0002132127,0.0003494358,0.0001111703,0.00008127884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000006383717,0.000004834314,0.000007392595,0.00185998,0.0003191905,8.2197e-7,0.000032891,0.00002409166,0.00002538271,0.00001639397,0.02332914,0.9743735],"study_design_scores_gemma":[0.0001363428,0.00004546426,0.00001337057,0.00156597,0.000438481,0.00006314954,0.00001892638,0.000006036454,0.00004034298,0.00003319261,0.9973539,0.0002848681],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001051359,0.9975335,0.0001328232,0.0000332029,0.0006731877,0.00043003,0.0005371148,0.0000147458,0.0005402411],"genre_scores_gemma":[0.00009536352,0.9948778,0.0002377788,0.00007148829,0.001158075,0.0006041517,0.0004937323,0.00006234979,0.002399331],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9740886,"threshold_uncertainty_score":0.9999936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02911586079589584,"score_gpt":0.3567508685642909,"score_spread":0.327635007768395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}