{"id":"W2903828136","doi":"10.20944/preprints201812.0117.v1","title":"Increasing Cellular Radioresistance by Simultaneous CRISPR/dCas9-Driven Overexpression of XPC and HR23B Genes","year":2018,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Radioresistance; CRISPR; Gene; Biology; HEK 293 cells; Cas9; DNA damage; Clonogenic assay; Cell biology; Cell; Genetics; DNA; Cell culture","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003332667,0.0006725951,0.0006395052,0.0003914514,0.0001996855,0.000783447,0.0004172227,0.0005421349,0.001993566],"category_scores_gemma":[0.0002510118,0.0002492463,0.0004294127,0.0002413142,0.0003390667,0.0003176036,0.0007367114,0.001180838,0.0008362293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004207647,"about_ca_system_score_gemma":0.0003039467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004826781,"about_ca_topic_score_gemma":0.0008112754,"domain_scores_codex":[0.999464,0.00005570801,0.00007506111,0.0001581079,0.0001745902,0.00007262168],"domain_scores_gemma":[0.9997557,0.00004788314,0.00005851432,0.00006000023,0.00003504245,0.00004291316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002002503,0.00001216792,0.00005716343,0.00003240485,0.000005881748,0.00003188223,0.000008323438,0.00006391435,0.9988028,0.00007016231,0.00003726949,0.0008580748],"study_design_scores_gemma":[0.000003988408,0.00004618468,0.0004843108,0.000003679171,0.0000118895,0.0001282617,0.000008796027,0.0004748521,0.996456,0.00002573214,0.002350959,0.000005292497],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9408008,0.002914702,0.04778488,0.0003948819,0.0001997338,0.0002418815,0.001686131,0.001297643,0.004679305],"genre_scores_gemma":[0.9694291,0.001179703,0.02200973,0.0001178227,0.00001681333,0.0001507079,0.001138294,0.0002545856,0.005703236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001993566,"threshold_uncertainty_score":0.006669164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0240986613982696,"score_gpt":0.3237785117460363,"score_spread":0.2996798503477667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}