{"id":"W2903854868","doi":"10.1101/488247","title":"Isolation and characterization of rare circulating autoantibody-producing cells from patients with muscle-specific kinase myasthenia gravis","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Myasthenia Gravis and Thymoma","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institutes of Health; Alexander S. Onassis Public Benefit Foundation; University of Oxford; Epilepsy Research UK; York University; Wellcome Trust; National Institute for Health and Care Research; National Institute of Allergy and Infectious Diseases; Muscular Dystrophy Association; Myasthenia Gravis Foundation of America","keywords":"Agrin; Myasthenia gravis; Autoantibody; Acetylcholine receptor; Neuromuscular junction; Autophosphorylation; Biology; Cell biology; Tyrosine kinase; Receptor tyrosine kinase; Immunology; Receptor; Antibody; Signal transduction; Biochemistry; Kinase; Neuroscience; Protein kinase A","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000116193,0.0003512335,0.0003767665,0.0007231954,0.0003769786,0.0005403825,0.000330456,0.0004985266,0.0018792],"category_scores_gemma":[0.0007443679,0.0001921344,0.0002392955,0.0004726604,0.0002428331,0.0002230318,0.0003610463,0.000357482,0.0006561836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001451745,"about_ca_system_score_gemma":0.00009707086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005559328,"about_ca_topic_score_gemma":0.0003739428,"domain_scores_codex":[0.99976,0.0000229428,0.00003309427,0.00009266976,0.00004249262,0.00004879452],"domain_scores_gemma":[0.9997434,0.00007647305,0.00003961854,0.00002801645,0.0000339925,0.00007859327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009466876,0.0004352535,0.4838066,0.0001644425,0.00008829238,0.03486997,0.001532319,0.0002016816,0.4398898,0.0004026009,0.0007875451,0.03687482],"study_design_scores_gemma":[0.0002458725,0.002748453,0.7957444,0.0000377275,0.0001776671,0.1614907,0.0009412681,0.001148435,0.02858708,0.0003319559,0.00850276,0.00004371177],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977928,0.0005658625,0.0007062607,0.00004952214,0.00001844995,0.00003583728,0.0001778887,0.00002482897,0.0006285652],"genre_scores_gemma":[0.9982923,0.0002709806,0.00052975,0.00009567294,0.00005198345,0.00002328587,0.000390977,0.00001289266,0.0003321293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0018792,"threshold_uncertainty_score":0.006286502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009925442370537716,"score_gpt":0.1974267468752152,"score_spread":0.1875013045046775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}