{"id":"W2903908034","doi":"10.1038/s41467-018-07799-2","title":"BRCA2 controls DNA:RNA hybrid level at DSBs by mediating RNase H2 recruitment","year":2018,"lang":"en","type":"article","venue":"Nature Communications","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":243,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Duke Cancer Institute; National Cancer Institute; Medical Research Council; Regione Lombardia; National Science Foundation; Associazione Italiana per la Ricerca sul Cancro; National Institute of General Medical Sciences; Fondazione Telethon; University of Oxford; Rutgers Cancer Institute of New Jersey; Institute of Genetics; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; American Cancer Society; Fondazione Cariplo","keywords":"RAD51; Genome instability; DNA damage; RNA; DNA repair; Biology; DNA; RNase P; Homologous recombination; Cell biology; RNase H; Molecular biology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009988869,0.0003262423,0.0001921934,0.0002148511,0.0002143404,0.0005625756,0.0002142484,0.0002650599,0.002837528],"category_scores_gemma":[0.0001290936,0.00018695,0.0001622898,0.00009329429,0.0002165073,0.0002147984,0.000254059,0.0003637846,0.001204757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004440473,"about_ca_system_score_gemma":0.000184238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005646378,"about_ca_topic_score_gemma":0.0008742644,"domain_scores_codex":[0.9998461,0.00001581977,0.000007242438,0.00006953142,0.00003078918,0.00003046794],"domain_scores_gemma":[0.9998804,0.00001494559,0.00002712755,0.00001293055,0.0000130502,0.00005150969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000496435,0.000008443262,0.000254011,0.00001440567,0.000002261775,0.00002714805,0.000008993517,0.00003211109,0.998914,0.00007545851,0.00006307014,0.0005505127],"study_design_scores_gemma":[0.000009163818,0.00004727557,0.007768448,0.0000029967,0.000004541592,0.0001510062,0.0000217149,0.0009705028,0.9878454,0.00005745906,0.003116722,0.000004791857],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827592,0.002754697,0.007085096,0.0001789953,0.00008481654,0.00002072464,0.0009947499,0.0005480167,0.005573627],"genre_scores_gemma":[0.9895499,0.0005499006,0.001724363,0.00008099339,0.00001886875,0.00002723445,0.0009449646,0.0001026782,0.007000977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002837528,"threshold_uncertainty_score":0.009492517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0435897135128657,"score_gpt":0.3237544996011389,"score_spread":0.2801647860882732,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}