{"id":"W2903910853","doi":"10.1021/acs.jmedchem.8b01310","title":"Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of <i>Plasmodium</i> M1 and M17 Aminopeptidases","year":2018,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Health and Medical Research Council; Canadian Institutes of Health Research; Canada Foundation for Innovation","keywords":"Hydroxamic acid; Plasmodium falciparum; Chemistry; Enzyme; Biochemistry; Plasmodium vivax; Antimalarial Agent; Molecular model; Stereochemistry; Combinatorial chemistry; Malaria; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001576021,0.0004976374,0.0003133281,0.0001857167,0.000110822,0.0002114561,0.0002550025,0.000193069,0.002429056],"category_scores_gemma":[0.0001021715,0.0001814323,0.0002226606,0.0001113583,0.0001333551,0.0001940442,0.000214544,0.0003970102,0.0004757364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001926077,"about_ca_system_score_gemma":0.0001680235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003228687,"about_ca_topic_score_gemma":0.0006538698,"domain_scores_codex":[0.9999002,0.00001906731,0.000009184366,0.00001532795,0.00001995753,0.00003634427],"domain_scores_gemma":[0.9999498,0.000008164118,0.00001571314,0.000004717393,0.000008755153,0.00001284612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004310308,0.0001438055,0.0002821439,0.0001543082,0.00002287257,0.0001150661,0.00001699214,0.0007026457,0.9820505,0.0005695296,0.000407245,0.01510382],"study_design_scores_gemma":[0.0001044517,0.001253555,0.001102141,0.000008349502,0.0000333626,0.0004396468,0.000008744079,0.001047327,0.9883479,0.00008185684,0.007567097,0.000005596536],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9678143,0.008251237,0.01012172,0.000260568,0.0001062718,0.0001653485,0.0006148836,0.0003386415,0.0123271],"genre_scores_gemma":[0.9850497,0.00538525,0.004634963,0.000165374,0.00003094878,0.00004398117,0.0005169088,0.00002717458,0.004145632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002429056,"threshold_uncertainty_score":0.00812602,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01308097249831955,"score_gpt":0.2729194836024076,"score_spread":0.2598385111040881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}