{"id":"W2903910853","doi":"10.1021/acs.jmedchem.8b01310","title":"Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of <i>Plasmodium</i> M1 and M17 Aminopeptidases","year":2018,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Health and Medical Research Council; Canadian Institutes of Health Research; Canada Foundation for Innovation","keywords":"Hydroxamic acid; Plasmodium falciparum; Chemistry; Enzyme; Biochemistry; Plasmodium vivax; Antimalarial Agent; Molecular model; Stereochemistry; Combinatorial chemistry; Malaria; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005172865,0.0002159908,0.0006123274,0.0001658213,0.00008965364,0.00002794179,0.00008858826,0.0001670584,0.0005205743],"category_scores_gemma":[0.0005162318,0.0001671938,0.0002287055,0.0002642134,0.0009447724,0.0002133599,0.00004794339,0.0004353662,0.000006354835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009935515,"about_ca_system_score_gemma":0.000223336,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008253865,"about_ca_topic_score_gemma":0.000002410927,"domain_scores_codex":[0.9977916,0.00002859304,0.0009555925,0.0002084597,0.0007819826,0.0002337639],"domain_scores_gemma":[0.9978765,0.00007255298,0.0007928339,0.000200511,0.000724557,0.0003331066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004385044,0.0001891986,0.01199454,0.0004865592,0.0001048875,0.0001998796,0.0002419718,7.1886e-7,0.981195,0.000008072921,0.004385719,0.0007548991],"study_design_scores_gemma":[0.002703553,0.0006748522,0.007016019,0.003010512,0.0002440372,0.001990116,0.0007057964,0.00003639191,0.9818151,0.00008159246,0.001578984,0.0001430281],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922961,0.0005048219,0.00009444591,0.001061535,0.00006120389,0.00007226525,0.00001659392,0.00001670464,0.00587633],"genre_scores_gemma":[0.9963852,0.0001279457,0.0003478756,0.0004128511,0.001633135,0.000001753761,0.00001265501,0.00001838028,0.001060167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004978523,"threshold_uncertainty_score":0.6817966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01308097249831955,"score_gpt":0.2729194836024076,"score_spread":0.2598385111040881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}