{"id":"W2903911519","doi":"10.1126/sciimmunol.aav4036","title":"Generation and molecular recognition of melanoma-associated antigen-specific human γδ T cells","year":2018,"lang":"en","type":"article","venue":"Science Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto; Sunnybrook Hospital","funders":"National Center for Research Resources; National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Krembil Foundation","keywords":"Antigen; Biology; Major histocompatibility complex; Immunology; Peptide; Melanoma; Cancer research; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004561453,0.0001171984,0.00017916,0.0002943454,0.0004795314,0.00002336792,0.0001821843,0.0001856697,0.001040664],"category_scores_gemma":[0.00006459865,0.0001140591,0.00004008244,0.0003506654,0.001894807,0.0002481374,0.00007876493,0.0001699212,0.0004706446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005681827,"about_ca_system_score_gemma":0.00004934941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009518528,"about_ca_topic_score_gemma":0.00001345009,"domain_scores_codex":[0.9988705,0.000155234,0.0003020624,0.0003333519,0.00004630432,0.0002925575],"domain_scores_gemma":[0.9991608,0.00002449424,0.0002053232,0.0002304475,0.0003663948,0.00001252326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003361355,0.00006535778,0.0001675886,9.818336e-7,0.0000345861,5.873666e-7,0.0002817366,1.965384e-7,0.9928645,0.0006558831,0.0008841389,0.005010786],"study_design_scores_gemma":[0.0005286124,0.0006403611,0.007286489,0.00001187563,0.000007241135,0.00002942333,0.0002001772,0.00001227953,0.9817172,0.0001716666,0.009275328,0.0001193159],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921653,0.001086928,0.0003060836,0.00007112708,0.003728428,0.0001275435,0.000002741643,0.00004192198,0.002469954],"genre_scores_gemma":[0.9988618,0.0002355683,0.00007608231,0.00009644961,0.00002768447,0.000005882544,0.00007525412,0.000008040166,0.0006131787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01114731,"threshold_uncertainty_score":0.9998725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02856520094113055,"score_gpt":0.2567523913071236,"score_spread":0.228187190365993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}