{"id":"W2903931322","doi":"10.1101/495242","title":"Disruption of IRElα through its Kinase Domain Attenuates Multiple Myeloma","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Microsemi (Canada)","funders":"Cancer Research Institute; Howard Hughes Medical Institute","keywords":"Unfolded protein response; Bortezomib; Cancer research; Multiple myeloma; XBP1; Endoplasmic reticulum; Secretion; Medicine; Kinase; Protein kinase A; Chemistry; Cell biology; Biology; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017304,0.0003969973,0.0003107032,0.000167566,0.0001678504,0.0003180102,0.0003138967,0.0003315333,0.001947561],"category_scores_gemma":[0.0001018971,0.0001496847,0.0002774463,0.0001354934,0.0003013498,0.0002584469,0.000171806,0.0007831272,0.0005735199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003591203,"about_ca_system_score_gemma":0.0002259871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002923894,"about_ca_topic_score_gemma":0.0003316743,"domain_scores_codex":[0.9998515,0.00002352799,0.00002275939,0.00003637763,0.00002903142,0.0000368069],"domain_scores_gemma":[0.9998913,0.0000140235,0.00004071238,0.00001492426,0.000009589809,0.00002949607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003937087,0.00009664113,0.0001019626,0.00004937848,0.000009338199,0.00002419423,0.000009251126,0.0001630772,0.9973388,0.0001743096,0.00009938844,0.001539972],"study_design_scores_gemma":[0.00005773308,0.0004727237,0.0008336771,0.000006932659,0.00001631813,0.0001339852,0.00001849287,0.0009012661,0.9943509,0.00004892716,0.003155581,0.00000350457],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890176,0.001994899,0.004636161,0.0004492583,0.0001683624,0.00007052554,0.001003512,0.0002978377,0.002361939],"genre_scores_gemma":[0.9938406,0.0007960951,0.002005219,0.00009981622,0.00001957462,0.00004691933,0.0005380095,0.00004155376,0.002612268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001947561,"threshold_uncertainty_score":0.006515205,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01162024292516821,"score_gpt":0.2355158643401098,"score_spread":0.2238956214149416,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}