{"id":"W2903962322","doi":"10.1182/blood-2018-99-112988","title":"A Global, Randomized, Placebo-Controlled, Phase 3 Study of Ibrutinib Plus Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (RCHOP) in Patients with Previously Untreated Non-Germinal Center B-Cell-like (GCB) Diffuse Large B-Cell Lymphoma (DLBCL)","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC; University of British Columbia","funders":"","keywords":"Ibrutinib; Vincristine; Rituximab; Medicine; Prednisone; Cyclophosphamide; Internal medicine; Phases of clinical research; Nuclear medicine; Oncology; Surgery; Chemotherapy; Lymphoma; Leukemia; Chronic lymphocytic leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001203477,0.0007866178,0.002938673,0.0003605954,0.0001786203,0.0000754266,0.0004006896,0.0002743597,0.0000820483],"category_scores_gemma":[0.0004465661,0.0005722133,0.0002360823,0.0008822724,0.0006135305,0.0001845939,0.0003856712,0.0002658332,0.00004102042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002440944,"about_ca_system_score_gemma":0.002883621,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002979897,"about_ca_topic_score_gemma":0.0006204403,"domain_scores_codex":[0.9939597,0.0005287137,0.001558753,0.001183531,0.001413632,0.001355652],"domain_scores_gemma":[0.9964643,0.0005351907,0.0006164619,0.001130974,0.000654635,0.0005984116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7044469,0.2266159,0.06333394,0.0006327688,0.000854434,0.0007808401,0.002276225,0.000001689948,0.00006023815,0.000002962209,0.0004452801,0.0005488518],"study_design_scores_gemma":[0.9786305,0.008097155,0.005387842,0.0005257337,0.001851612,0.0001328959,0.0004838836,0.003582907,0.0007198177,0.000004623471,0.00009045474,0.0004925839],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854748,0.0009216499,0.00005115434,0.00002134121,0.0001235762,0.01135657,0.000173683,0.00008944139,0.001787784],"genre_scores_gemma":[0.9979074,0.0001404834,0.000339822,0.0001224976,0.0001403878,0.0005226126,0.0001252013,0.0001027471,0.0005988542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2741837,"threshold_uncertainty_score":0.9996729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004923132404732803,"score_gpt":0.2569880009048837,"score_spread":0.2520648685001509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}