{"id":"W2903991675","doi":"10.1111/jvim.15382","title":"Effects of the potassium-sparing diuretic amiloride on chemotherapy response in canine osteosarcoma cells","year":2018,"lang":"en","type":"article","venue":"Journal of Veterinary Internal Medicine","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"OVC Pet Trust","keywords":"Amiloride; Medicine; Pharmacology; Doxorubicin; Carboplatin; Apoptosis; Downregulation and upregulation; Chemotherapy; Cancer research; Internal medicine; Cisplatin; Biology; Chemistry; Biochemistry; Sodium","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002210713,0.0001781858,0.0004161591,0.0002345501,0.0001572678,0.0002239621,0.000150819,0.0002087614,0.0008976652],"category_scores_gemma":[0.0001406854,0.00008252713,0.0002714518,0.0002210942,0.000151622,0.0001873087,0.0001380716,0.0004534538,0.0002046427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002862481,"about_ca_system_score_gemma":0.0002323913,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006891044,"about_ca_topic_score_gemma":0.001793819,"domain_scores_codex":[0.9998052,0.00003592353,0.00002768891,0.00003473245,0.00006037999,0.00003616512],"domain_scores_gemma":[0.9998784,0.00002850887,0.00002595193,0.00001185327,0.00002492381,0.00003032751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000968492,0.00029075,0.001423505,0.0001419577,0.00002016286,0.00006737241,0.00006149106,0.0001623709,0.9922752,0.00005105719,0.0002229153,0.004314679],"study_design_scores_gemma":[0.0001181045,0.007245289,0.02381524,0.00001394294,0.00009072197,0.0003455074,0.0001751658,0.001741646,0.9618618,0.00004693053,0.004530271,0.00001530735],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964211,0.001882024,0.0004124093,0.0001148736,0.00003799144,0.00003365874,0.0003043206,0.00002078042,0.0007727949],"genre_scores_gemma":[0.9969304,0.0009400509,0.0009272365,0.00005706312,0.00001397551,0.0000476323,0.0004765396,0.000004809568,0.0006023042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008976652,"threshold_uncertainty_score":0.003003001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01016291652364682,"score_gpt":0.2770182862661887,"score_spread":0.2668553697425419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}